Epidermolysis bullosa

Question 1

3 major subgroups of epidermolysis bullosa

Answer 1

Intraepidermal (ie simplex)-> heals without scaring
Junctional-> manifest as atrophy
Dermal (dystrophic)-> heals with scaring

Question 2

Epidermolysis bullosa simplex

Answer 2

AD inheritance
Split is in the epidermal nasal cells
Blistering on hands/feet and other sites of trauma that heal without scaring

Question 3

Junctional epidermolysis bullosa

Answer 3

AR inheritance
Severe generalized blistering of skin without palms/soles involved
Mucous membranes involvement is common
Dentition May be defective

Question 4

Dystrophic epidermolysis bullosa

Answer 4

AR or AD inheritance
Clinical variability in severity
AR form can get mitten deformity due to repeated blistering and scaring