Epidemiology Flashcards
Definition of Epidemiology
The study of the distribution and determinants of healthrelated states or events in specified populations, and the
application of this study to control health problems.
What is an infectious disease
An illness due to a specific infectious agent or its toxins
- that arises through transmission (i.e., can be spread) of
that agent or its products
- from an infected person, animal, or reservoir to a
susceptible host,
- either directly or indirectly through an intermediate
host, vector, or the inanimate environment
What is zoonosis
Diseases that Spread from animals to humans
Define Epidemiologically linked
A case in which the infected person has had contact with one or more infected person and transmission of the agent by usual mode of transmission is plausible
What’s a cluster of disease
Group of cases of disease
believed to be greater than
expected & associated in time and
space
What is an outbreak
An increase in the
observed number of cases of a
disease or health problem
compared to the expected number
Differentiate between Endemic, Epidemic, and Pandemic
Endemic = disease consistently present, but limited to a
particular region
• Epidemic = unexpected increase in the number of
disease cases in a specific geographic area (outbreak
over larger area)
• Pandemic = disease’s growth is exponential, affecting
several countries / global spread
What does the Miasma theory state
medical theory on how epidemics
spread by “bad air” or poisonous
vapours
• Disease caused by bad
environments; not transmissible
from human to human
• From the time of Hippocrates in
Ancient Greece, well established in
middle ages in Europe and China
Germ Theory by Robert Kosh and Louis Pasteur state that micoorganisms can cause disease, how did that test this theory?
- The suspected causative agent must be present in all diseased organisms but absent in all healthy organisms
- The causative gent must be isolated from diseased organisms and grown in pure culture
- The cultured agent must cause the same disease when inoculated into a healthy susceptible organism
- The same causative organism must be reisolated from the inoculated organism
Important features of infectious disease
1.The organisms that cause infectious diseases are
necessary causes
2.Can have latent period of asymptomatic disease
3.Immunity (natural or vaccine induced) can be
acquired
4.One Health
What is a reservoir, give 4 examples
Reservoir = An ecological niche
where a pathogen lives & multiplies
• WHERE (and/or WHO) does it come from?
Examples:
o Human: Syphilis, HIV, Hepatitis
o Animal: Rabies, Brucellosis
o Soil: Histoplasma (fungus), tetanus
o Water: Legionella, cholera
The Means or Modes of transmitting of infections or infectious organisms
Direct Transmission
i.e. person to person
- Mucous membrane to mucous membrane
o E.g.Sexually transmitted diseases
- Across placenta
o E.g. Toxoplasmosis
- Blood
o E.g. Hepatitis B
- Skin to skin
o E.g. Herpes type 1
- Sneezes, coughs
o E.g. Influenza, TB
Indirect (i.e. by a common vehicle or vector)
- Food-borne
o E.g. salmonella (typhoid)
- Water
o E.g. Cholera, Hepatitis A
- Objects
o E.g. scarlet fever (toys in in a nursery)
- Vectors (mosquitoes)
o E.g. malaria
What are measures of occurrence (define them)
Incidence- Number of new cases over a period of time
Prevalence -Burden of infection or disease in
community
o Prevalence = Incidence x Duration
Challenges with prevalence: Some infectious diseases have short duration/occurs repeatedly
▪ Many infectious diseases have a short duration and may occur repeatedly, and thus
prevalence is not as important a measure in these instances. E.g., Diarrhoeal/respiratory
infections (point prevalence may be low but annual incidence high)
When is prevalence useful: Some infectious diseases are chronic in nature
▪ Some infectious agents have a chronic nature, and both incidence and prevalence are
important measures with prevalence providing a more accurate measure of risk of
infection and the size of the infectious pool . E.g. Hep B, TB, HIV
Why is it important to
understand time periods of
infection?
To monitor and investigate
outbreaks
- To know how fast the
infection/disease will
spread/decrease
What is the Incubation period
Why is it useful.
The time between exposure to an infectious agent and the onset of symptoms or signs of infection
Variation of incubation period is due to:
-Dose; Route; Rate of replication; Host factors
Allows one to determine:
-when infection occurred
-who could be a contact, length of quarantine period
What is the latent phase, how is it different from incubation phase
Latent Period
Time period from successful infection until the development of infectiousness.
Infectious period is when infection can be transmitted from one person to another.
What is infectivity and how to calculate it
Infectivity = how infectious an agent is, the ability of an agent to cause infection in a susceptible host
Secondary attack rate=Secondary infections/total number of contacts
=now infected/total-already infected *100
What is pathogenicity and Virulence and how to calculate it
Pathogenicity = ability of an agent to induce disease (any symptoms)
=diseased individuals / infected individuals
Virulence = severity of infection
• Case fatality rate = number of deaths / number of cases ( infections)
• Varies widely by pathogen: common cold (Rhinovirus) vs small
pox
Outline the Stages of progression from exposure to outcome
(Slide 34)
Infectivity ➡️ pathogenicity ➡️Virulence
Risk leads to:
From exposure, to infection there’s infectivity
From infection (sub clinical), to disease there’s pathogenicity
From Disease to outcome there’s Virulence.
Rank the different types of diseases with High, Intermediate, Low and Very low:
infectivity
Pathogenicity
Virulence
Slide 36
- What determines how many people will
die from an infectious disease?
High infectivity and high Virulence
5 most deadly diseases
- Tuberculosis
- Measles
- Malaria
- Influenza
- Diarrhoeal
diseases
TMMID- The Most Mortal Infectious Diseases
What follows EXPOSURE to an infectious agent?
i.e., what are all the possible outcomes?
No foothold
Clinical infection
Subclinical infection
Carriage/colonisation
Death
Immunity
Carriage
Non immunity
Define reproductive number
Reproductive numbers estimate the average number of secondary cases
originating from a primary case during their entire infectious period
• Basic Reproductive Number (R0
)
• “The expected number of secondary cases from a single case introduced
into a totally susceptible population”
• Effective Reproductive Number (Rt or Re)
• The reproductive number at a specified time in a partially susceptible
population
Reproductive numb