Epidemiology Flashcards

1
Q

Definition of Epidemiology

A

The study of the distribution and determinants of healthrelated states or events in specified populations, and the
application of this study to control health problems.

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2
Q

What is an infectious disease

A

An illness due to a specific infectious agent or its toxins
- that arises through transmission (i.e., can be spread) of
that agent or its products
- from an infected person, animal, or reservoir to a
susceptible host,
- either directly or indirectly through an intermediate
host, vector, or the inanimate environment

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3
Q

What is zoonosis

A

Diseases that Spread from animals to humans

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4
Q

Define Epidemiologically linked

A

A case in which the infected person has had contact with one or more infected person and transmission of the agent by usual mode of transmission is plausible

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5
Q

What’s a cluster of disease

A

Group of cases of disease
believed to be greater than
expected & associated in time and
space

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6
Q

What is an outbreak

A

An increase in the
observed number of cases of a
disease or health problem
compared to the expected number

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7
Q

Differentiate between Endemic, Epidemic, and Pandemic

A

Endemic = disease consistently present, but limited to a
particular region
• Epidemic = unexpected increase in the number of
disease cases in a specific geographic area (outbreak
over larger area)
• Pandemic = disease’s growth is exponential, affecting
several countries / global spread

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8
Q

What does the Miasma theory state

A

medical theory on how epidemics
spread by “bad air” or poisonous
vapours
• Disease caused by bad
environments; not transmissible
from human to human
• From the time of Hippocrates in
Ancient Greece, well established in
middle ages in Europe and China

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9
Q

Germ Theory by Robert Kosh and Louis Pasteur state that micoorganisms can cause disease, how did that test this theory?

A
  1. The suspected causative agent must be present in all diseased organisms but absent in all healthy organisms
  2. The causative gent must be isolated from diseased organisms and grown in pure culture
  3. The cultured agent must cause the same disease when inoculated into a healthy susceptible organism
  4. The same causative organism must be reisolated from the inoculated organism
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10
Q

Important features of infectious disease

A

1.The organisms that cause infectious diseases are
necessary causes
2.Can have latent period of asymptomatic disease
3.Immunity (natural or vaccine induced) can be
acquired
4.One Health

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11
Q

What is a reservoir, give 4 examples

A

Reservoir = An ecological niche
where a pathogen lives & multiplies
• WHERE (and/or WHO) does it come from?
Examples:
o Human: Syphilis, HIV, Hepatitis
o Animal: Rabies, Brucellosis
o Soil: Histoplasma (fungus), tetanus
o Water: Legionella, cholera

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12
Q

The Means or Modes of transmitting of infections or infectious organisms

A

Direct Transmission
i.e. person to person
- Mucous membrane to mucous membrane
o E.g.Sexually transmitted diseases
- Across placenta
o E.g. Toxoplasmosis
- Blood
o E.g. Hepatitis B
- Skin to skin
o E.g. Herpes type 1
- Sneezes, coughs
o E.g. Influenza, TB

Indirect (i.e. by a common vehicle or vector)
- Food-borne
o E.g. salmonella (typhoid)
- Water
o E.g. Cholera, Hepatitis A
- Objects
o E.g. scarlet fever (toys in in a nursery)
- Vectors (mosquitoes)
o E.g. malaria

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13
Q

What are measures of occurrence (define them)

A

Incidence- Number of new cases over a period of time
Prevalence -Burden of infection or disease in
community
o Prevalence = Incidence x Duration

Challenges with prevalence: Some infectious diseases have short duration/occurs repeatedly
▪ Many infectious diseases have a short duration and may occur repeatedly, and thus
prevalence is not as important a measure in these instances. E.g., Diarrhoeal/respiratory
infections (point prevalence may be low but annual incidence high)
When is prevalence useful: Some infectious diseases are chronic in nature
▪ Some infectious agents have a chronic nature, and both incidence and prevalence are
important measures with prevalence providing a more accurate measure of risk of
infection and the size of the infectious pool . E.g. Hep B, TB, HIV

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14
Q

Why is it important to
understand time periods of
infection?

A

To monitor and investigate
outbreaks
- To know how fast the
infection/disease will
spread/decrease

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15
Q

What is the Incubation period

Why is it useful.

A

The time between exposure to an infectious agent and the onset of symptoms or signs of infection

Variation of incubation period is due to:
-Dose; Route; Rate of replication; Host factors

Allows one to determine:
-when infection occurred
-who could be a contact, length of quarantine period

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16
Q

What is the latent phase, how is it different from incubation phase

A

Latent Period
Time period from successful infection until the development of infectiousness.
Infectious period is when infection can be transmitted from one person to another.

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17
Q

What is infectivity and how to calculate it

A

Infectivity = how infectious an agent is, the ability of an agent to cause infection in a susceptible host
Secondary attack rate=Secondary infections/total number of contacts
=now infected/total-already infected *100

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18
Q

What is pathogenicity and Virulence and how to calculate it

A

Pathogenicity = ability of an agent to induce disease (any symptoms)
=diseased individuals / infected individuals

Virulence = severity of infection
• Case fatality rate = number of deaths / number of cases ( infections)
• Varies widely by pathogen: common cold (Rhinovirus) vs small
pox

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19
Q

Outline the Stages of progression from exposure to outcome

A

(Slide 34)

Infectivity ➡️ pathogenicity ➡️Virulence

Risk leads to:
From exposure, to infection there’s infectivity
From infection (sub clinical), to disease there’s pathogenicity
From Disease to outcome there’s Virulence.

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20
Q

Rank the different types of diseases with High, Intermediate, Low and Very low:
infectivity
Pathogenicity
Virulence

A

Slide 36

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21
Q
  1. What determines how many people will
    die from an infectious disease?
A

High infectivity and high Virulence

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22
Q

5 most deadly diseases

A
  1. Tuberculosis
  2. Measles
  3. Malaria
  4. Influenza
  5. Diarrhoeal
    diseases

TMMID- The Most Mortal Infectious Diseases

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23
Q

What follows EXPOSURE to an infectious agent?
i.e., what are all the possible outcomes?

A

No foothold
Clinical infection
Subclinical infection
Carriage/colonisation

Death
Immunity
Carriage
Non immunity

24
Q

Define reproductive number

A

Reproductive numbers estimate the average number of secondary cases
originating from a primary case during their entire infectious period
• Basic Reproductive Number (R0
)
• “The expected number of secondary cases from a single case introduced
into a totally susceptible population”
• Effective Reproductive Number (Rt or Re)
• The reproductive number at a specified time in a partially susceptible
population
Reproductive numb

25
How would you calculate reproductive number How would you interpreted the results
Reproductive number = Infectiousness X Number of contacts X Duration of infectiousness Interpreting R0 • if < 1 disease will eventually disappear • if = 1 disease will be endemic • if > 1 there will be an epidemic
26
What is herd immunity
Here immunity is protection against infections in a population either directly through vaccinations or acquired immunity It is the level of immunity required to prevent epidemics
27
Steps for an outbreak investigation
Verify Diagnosis Establish existence of outbreak Identify and count cases Describe epidemiology Formulate and test hypothesis Assess local response and address gaps Set up control measures Communicate findings Intensify Surveillance Count cases
28
Outline the Phases of an Epidemic (using COVID-19 as an example)
Phase 1: sporadic cases Phase 2: clusters Phase 3: main wave Phase 4: Full epidemic Phase 5: late epidemic
29
What are the challenges encounters when controlling infectious diseases
Re-emergence of old diseases –cholera, typhoid • Changes in environment, agriculture & food-processing, movement of people and goods, behaviors • Increased density of populations (refugees) • Increased susceptibility • Bioterrorism
30
What are the advances in the control of infectious diseases
Lab techniques, molecular epidemiology – DNA finger printing • Epidemiology • Vaccines • Communication
31
What are non communicable diseases
Diseases that can not be spread from one person to an other They have a long duration Slow progression Complex aetiology
32
Tabulate the differences between communicable and non communicable diseases
33
WHAT ARE NCDs?
known as ‘chronic diseases’, they are illnesses that can NOT be spread from person to person
34
Differences between NCDs and Communicable diseases
NCDs: Gradual onset Long natural history Care predominates over cure Multidisciplinary Multiple causes Prolonged treatment Prolonged follow up Quality of life after treatment is often affected, back to normalcy in communicable
35
Why are NCDs important
NCDs are the leading cause of death and disability in SA • Globally, NCDs kill 41 000 000 people/year (74% of global deaths) • 17million die from an NCD <70yrs of age • 86% of these premature deaths in LMICs • 77% of all NCD deaths are in LMICs • WHO estimates deaths from NCDs will increase globally by 17% over the next 10years and Africa will experience a 27% • Approx. 28million ADDITIONAL deaths
36
5 Main Types of NCDs
1. Cardiovascular disease 2. Chronic Respiratory disease 3. Cancer 4. Diabetes 5. Mental healthy
37
5 Main Risk factors of NCDs
1. Smoking 2. Unhlealthy diet 3. Lack of physical exercise 4. Alcohol use (harmfully) 5. Air pollution
38
What are modifiable and non modifiable risk factors, give 5 examples of MRF and 3 examples of NMRF
MRF- risk factor can be reduced or controlled by intervention reducing probability if diseases Examples: smoking, alcohol use, unhealthy diet, lack of physical activity, environmental eg air pollution NMRF- cannot be changed by intervention Eg sex, age, family history (genetics)
39
Outline the Epidemiological Transition stages
Stage 1: pestilence and famine- infections and parasitic diseases, accidents, and human attacks are the major cause of death, high mortality in 20-40y/o Stage 2: receding epidemics- fall in mortality (35-50y/o) intro to modern health care and health technologies, improved sanitation, nutrition and medicine Stage 3: degenerative and human created diseases- decrease in deaths from infectious diseases and increase in chronic disorders ass with aging Stage 4: stage of delayed degenerative diseases- decrease-the major degenerative causes of death are cardiovascular diseases and cancers. Life expectancy improves due to medical advances. Stage 5: Reemergence of infectious and parasitic diseases- infectious disease that have been eradicated have returned and new ones have emerged
40
What is the Socio-ecological theory
Theory that conceptualises health and broadly focuses on how health is affected by interaction between individual, the community, and the physical, social and political environment. Individuals➡️ Relationships➡️Community➡️Societal
41
How can Socio-Ecological Theory address NCDs
Individual • Nutrition • Education • Exercise Interpersonal • Exercise buddies • Community groups to create healthy menus • Gardening clubs Community • Grocery store items – increase healthy and reduce processed • Create walking trails/parks/indoor active events • Workplace health programs Social • Sugar tax • Ban junk food at schools • Maintain bike trails/hiking trails e
42
Describe Difference between sensitivity and Specificity (Both are screening tests)
Sensitivity is Proportion of the individuals who have the disease and test positive i.e true positive Specificity is Proportion of individuals who don’t have the disease who test negative I.e true negative
43
Positive predictive value and Negative Predictive Value
Positive Predictive Value: Proportion of individual who test positive who actually have the diseases Negative Predictive Value: Proportion of individuals who test negative who don’t have the disease
44
PPV and NPV are affected by Sensitivity, Specificity and Prevalence in what way
PPV • Increases with increasing prevalence • Increases with increasing specificity NPV • Increases with decreasing prevalence • Increases with increasing sensitivity
45
DEFINE INJURIES AND VIOLENCE
Injury is the physical damage that results when a human body is suddenly subjected to energy exceeding threshold of physiological tolerance Violence is the intentional use of force, power, threatened or actual, against oneself, another person or group or community. With high likelihood to cause injury, death, psychological harm etc.
46
What are the 3Es of prevention
Education Enforcement Engineering/environmental modification
47
Road Safety 2.0 The systems approach
factors influencing crash severity - e.g. helmets, seatbelts, child seats • factors influencing crash involvement – e.g. AOD, cell phones, roadworthiness • factors influencing exposure to risk – alternative modes, vehicle separation
48
What are the 6 key intervention themes by WHO IN injuries
Investing in early interventions Strengthening the community Reduce income inequality Increasing positive adult involvement Changing cultural and social norms Improve criminal justice and social welfare
49
What are the 3 Es of prevention
Enforcement Education Engineering or Environmental modification
50
What are the problems or challenges with disease model
Works well for individual events but difficult to synthesise at a population level Leads to victim-blaming and helplessness The Es foster a silo-based approach to prevention ( silo approaches are discrete, not sharing valuable information with other members of company)
51
What is the systems approach to Road injuries
factors influencing crash severity - e.g. helmets, seatbelts, child seats • factors influencing crash involvement – e.g. AOD, cell phones, roadworthiness • factors influencing exposure to risk –alternative modes, vehicle separation
52
INTERVENTIONS FOR PREVENTION OF TB AND HIV/AIDS
Improved testing for HIV/TB Improved screening Improved drugs PMTCT program ART on all people living with HIV regardless of CD4 count TB Prevention for all people living with HIV Adherence to clubs
53
Challenges in preventing TB and HIV/AIDS
Maintaining people living with HIV/TB in care Integrating TB and HIV care (previously disease specific programs) Stigma and discrimination Slow uptake of voluntary medical make circumcision
54
Five main causes of ill health
1. Infectious diseases, including HIV/AIDS and tuberculosis 2. Mental health conditions 3. Injuries, including road traffic injuries and violence-related injuries 4. Cardiovascular diseases 5. Childhood diseases
55
What is Health Policy
Ideas, plans and actions taken to achieve specific health care goals. Defines vision for the future Assigns specific roles to different groups Builds consensus and informs people
56
How are Legislative Policies made
Political manifesto Green paper: Document with proposals White paper: concrete proposals for legislature change Bill: Act presented to parliament by Minister, Deputy Minister, MEC or Deputy of MEC Regulation of the Act: specifics of the Act Supported by Public Consultation
57
What is the SA Constitution of 1996
The state must take reasonable legislature and other measures within its available resources to achieve progressive realisation of the rights of people to have access to health care services include reproductive health care. No one may be refused emergency medical service Every child has right to basic health care services Everyone has right to environment not harmful Local government responsible for municipal health services Provincial gov can assign any provincial function to local government if LG has capacity to perform.