Eph/ephrin signalling pathway

Question 1

What are EPH receptors and what family are they from?

Answer 1

EPH receptors are trans-membrane proteins from the Receptor Tyrosine Kinase family.

Question 2

What does downstream transduction of the signal involve?

Answer 2

Downstream transduction of the signal involves the oligomerisation and cytoplasmic cross-phosphorylation of the receptors.

Question 3

How are EPHs classified and according to what?

Answer 3

EPHs are classified in type-A and type-B, according to the Ephrin ligand they bind to

Question 4

What are ephrin-A ligands attached to?

Answer 4

Ephrin-A ligands are attached to the membrane by a lipid modification

Question 5

What are ephrin-B ligads?

Answer 5

Ephrin-B ligands are transmembrane proteins

Question 6

What can EPH receptors bind to either of and what exception is there?

Answer 6

EPH receptors can only bind to either Ephrin-A or Ephrin-B ligands, with one exception: EPHA4, which can bind to both types of ligands.

Question 7

What does an interaction between Ephrin ligands and EPH receptors lead to?

Answer 7

The interaction between Ephrin ligands and EPH receptors leads to a bidirectional response – in both the receiving and the signalling cell.