Enzymes in Clinical Medicine Flashcards
What are the enzymes used in diagnosis and prognosis?
Plasma enzymes & isoenzymes (differentiate tissue- specific enzyme activity).
What is the functional role of plasma enzymes?
They perform physiological roles.
Examples of functional plasma enzymes:
Thrombin & lipoprotein lipase.
What is the non-functional role of plasma enzymes?
They are released during cellular damage.
isoenzymes (differentiate tissue- specific enzyme activity): what is the role of LDH?
It is increased in myocardial infarction and hemolytic anemia.
isoenzymes (differentiate tissue- specific enzyme activity): What is the role of CK?
It is elevated in muscle damage.
isoenzymes (differentiate tissue- specific enzyme activity): What is the role of CK-2?
Used for early detection of myocardial infarction.
What are the enzymes that are used for therapeutic uses?
- Streptokinase.
- Asparaginase.
What is the role of streptokinase?
Dissolves blood clots in myocardial infarction.
What is the role of asparaginase?
Treats leukemia by depleting asparagine + Essential for tumor viability.
What enzymes are used as diagnostic reagents?
Purified enzymes:
1. Glucose oxidase.
2. Uricase.
3. Urease.
What are purified enzymes used for?
Blood component analysis.
