Enzymes (E4)

Question 1

Characteristics of enzymes

Answer 1

Have a temperature optimum (98.6 F)
Have a Ph optimum (7.35-7.45)
Have a rate at which they speed up chemical reactions
Have a specificity of the enzymatic binding site matching the substrate (specificity, size-shape-charge)

Question 2

Enzymatic binding site inhibitors

Answer 2

Competitive
Non competitive
Suicide

Question 3

Competitive enzymatic inhibitors

Answer 3

Chemicals compete equally with normal substrate for the enzymatic binding site, when bound prevent the enzymatic reactions (dose dependent- amount of enzymatic inhibition is controlled by the does of competitive inhibitor)

Question 4

Non competitive enzymatic inhibitors

Answer 4

Chemicals bind more preferentially to the enzymatic inhibition site than normal substrate, when bound prevent enzymatic reactions

Question 5

Suicide enzymatic inhibitors

Answer 5

Chemical that bind permanently to the enzymatic binding site and stops from ever binding (in all stops enzymatic reactions)

Question 6

Competitive example

Answer 6

Angiotensin I to angiotensin II goes through ACE inhibitor

Glycolysis to glucose, atps add up until arsenic is present (when present all atp is no longer present)

Question 7

Non competitive example

Answer 7

Co bind to 200-400x more preferentially to hemoglobin to o2, so it is like a cycle of 3 o2’s and 1 co around Hb-a

List of human enzymes/ list of bacteria enzymes
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Question 8

Suicide example

Answer 8

(In the liver) -94mV inside and +79mV, enzyme attaches ti liver where 3Na+ leave the leave and 2 kt enter

Best antibiotics are suicide inhibitors