Enzymes 1 Flashcards
1
Q
Kinase group
A
Transfer phosphate groups from one molecule to another using a nucleotide phosphate as donor
2
Q
Aminotransferase
A
Transfer amino acids using pyridoxine phosphate
3
Q
Examples of co enzymes
A
- Tetrahydrofolate
- Pyridoxal phosphate
- Co enzyme A
4
Q
Competitive Inhibition
A
Vmax is unchanged, but km increases.
5
Q
Examples of competitive inhibitors
( ASRC)
A
- Atorvastatin = 3H3MG CoA Reductase = Hypolipidaemia.
6
Q
Competitive Inhibitor
A
- Sildenafil = cGMP PDE5 = Erectile dysfunction.
7
Q
Competitive Inhibitor
A
Ritonavir = HIV Protease = Antiretoviral
8
Q
Competitive Inhibitor
A
Captopril = ACE = Antihypertensive.
9
Q
Non competitive Inhibitors = Vmax is reduced, Km us constant.
(ANDT)
A
Acetazolamide = carbonic anhydrase = Glaucoma, Weak diuretic.
10
Q
Non competitive Inhibitors
A
- Nevirapine = HIV reverse transcriptase = Antiretroviral.
11
Q
Non competitive Inhibitors
A
- Doxycycline = Collagenase = Arthritis.
12
Q
Non competitive Inhibitors
A
- Tacrine = AChe = Alzheimer’s disease
13
Q
Uncompetitive Inhibitors, Vmax decreases, Km decreases [ LFC]
A
- Lithium = Impase = Mania
14
Q
Uncompetitive Inhibitors
A
- Finasteride = 5 alpha reductase = BPH
15
Q
Uncompetitive Inhibitors
A
- Camptothecin = Topoisomerase = Anticancer.
