Enzyme replacements in Gluconeogenesis Flashcards
Pyruvate Kinase (Glycolysis)
Pyruvate Carboxylase and Phosphoenolpyruvate carboxykinase (Gluconeogenesis)
Pyruvate carboxylase (replacement of pyruvate Kinase)
Catalyzes the conversion of pyruvate to oxalacetate. The metabolically irreversible reaction is coupled to the hydrolysis of one molecule of ATP.
Oxaloacetate can enter the citric acid cylce or serve as a precursor for glucose biosynthesis.
Phosphoenolpyruvate carboxykinase
Catalyzes the conversion of oxaloacetate to phosphoenolpyruvate.
The enzyme found in bacteria, protists, fungi and plants use ATP as the phosphoryl group donor in the decarboxylation reaction. The animal version uses GTP.
Phosphofructokinase-1 (Glycolysis)
Fructose 1,6 -bisphosphatase
Fructose 1,6-bisphosphatase
This enzyme catalyzes the conversion of fructose 1,6-bisphosphate to fructose 6-phosphatae
Hexokinase (Glycolysis)
Glucose 6-phosphatase
Glucsoe 6-phosphatase
The enzyme that catalyzes the final step of gluconeogenesis, the hydrolysis of glucose 6-phosphate to form glucose.