Enzyme Reactions - Inhibitors

Question 1

What are competitive inhibitors?

Answer 1

competitive inhibitors have a similar shape to the substrate so they can bind to the active site

this stops the substrate forming an E-S complex

the proportion of substrate to competitive inhibitor will affect how much the rate of reaction changes - e.g. the more inhibitor the less substrate or less inhibitor more substrate

Question 2

What is a non-competitive inhibitor?

Answer 2

non-competitive inhibitor binds to the enzyme but not at the active site
changes the shape of the active site
no more E-S complexes are formed
changing the concentration of substrate wont make any difference