Enzyme Nomenclature and Co-enzyme Chemistry Flashcards

1
Q

what are the 6 classes of enzymes?

A

oxidoredictases, lyases, hydrolases, ligases, transferases, isomerases

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2
Q

what are the 4 classes of proteases?

A

metallo-, cysteine, aspartic, serine

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3
Q

what inactivates serine proteases?

A

serpins

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4
Q

how do serpins work?

A

bind to serine proteases as a “substrate” and cause an irreversible conformational change which inhibits the enzyme

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5
Q

how are proteases activated?

A

proteolytic cleavage

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6
Q

what are the 3 stages of a protease?

A

prepro-enzyme, pro-enzyme, mature protease

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7
Q

what are the two functions of a metal ion?

A

structural: helps protein stay folded
catalytic: participates in chemistry at the active site of the protein

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8
Q

what do oxidoreductases do?

A

catalyze redox reactions

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9
Q

what are common oxidoreductase names?

A

dehydrogenase, peroxidase, reductase, oxidase, hydroxylase, cytp450, oxygenase

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10
Q

what do transferases do?

A

move a group from one compound to another

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11
Q

what do hydrolases do?

A

break C-O,N,S bonds by cleaving water

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12
Q

what are common hydrolases?

A

protease, peptidase, esterase, phosphatase, urease

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13
Q

what do lyases do?

A

cleave C-C,O,N,S bonds by means other than hydrolysis

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14
Q

what are the reverse lyases called?

A

synthases

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15
Q

what are common lyase names?

A

decarboxylase, aldolase

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16
Q

what do isomerases do?

A

change structure without cleaving or adding anything

17
Q

what do ligases do?

A

form C-C,O,N,S bonds w/ ATP

18
Q

what are common ligase names?

A

synthetase, ligase

19
Q

what makes up a serine proteases active site?

A

ser-Asp-His catalytic triad

20
Q

what are 2 clinically important serps?

A

anti thrombin: inhibits coagulation

alpha-1-antitrypsin: inhibits neutrophil elastases in lungs (protective)