Enzyme inducers/ inhibitors Flashcards
1
Q
what are the enzyme inducers
A
PCBRAS- phenytoin, carbamazepine, barbiturates, rifampicin, alcohol (chronic), sulphonylureas
2
Q
what are the enzyme inhibitors
A
AODEVICES- allopurinol, omeprazole, disulfiram, erythromycin, valproate, isoniazid, cipro, ethanol (acute), sulphonamides
3
Q
if INR is increased is this due to enzyme induction or inhibition
A
inhibition
4
Q
what does St Johns do to P450
A
inducer-causing the INR to decrease
5
Q
what does cranberry juice do to P450
A
inhibitor- causing the INR to increase
6
Q
what does grapefruit juice do to P450
A
inhibitor
