Environmental Hazards Flashcards
The _____ is the gold standard for determining health effects of lead.
Blood Lead Level (BLL)
A BLL of _____ is considered a level of concern for public health purposes.
≥ 10 μg/dL
The _____ of young children is the most common pathway by which lead enters the body.
nonnutritive hand-to-mouth activity
Most retained lead accumulates in _____, where it may reside for _____.
bone
years
The _____, present in all cells, has 3 enzymes susceptible to lead inhibitory effects.
Heme Pathway
The accumulation of excess amounts of _____ and other heme precursors is toxic.
Protoporphyrin
A second mechanism of lead toxicity works via its competition with _____.
Calcium
A third mechanism of lead toxicity prevents development of the normal _____ brain structure.
tertiary
Lead Encephalopathy is more likely to be observed in children with BLLs _____.
> 100 μg/dL
Children with BLLs _____ are 2x as likely to have GI complaints.
> 20 μg/dL
CNS symptoms in lead poisoning are related to _____.
cerebral edema
increased ICP
There is no clear cutoff BLL value for the appearance of hyperactivity, but it is more likely to be observed in children who have levels _____.
> 20 μg/dL
_____ is preferred to capillary sampling because chances of false-positive and false-negative results are less.
Venous Sampling
A confirmed venous BLL of _____ requires prompt chelation.
≥ 45 μg/dL
Lead toxicity is treated with chelation therapy using _____.
2,3-dimercaptosuccinic acid (DMSA)
CaNa2EDTA
British Anti-Lewisite (Dimercaprol)
Penicillamine