Entities 1

Question 1

Key virulence factors from Bacillus anthracis

Answer 1

Lethal Factor- A toxin, cell death, CNS depression
Edema Factor- A toxin, disrupts cell membrane via increased cAMP, water efflux
Protective Antigen- B toxin, toxoid

Question 2

Key histo features of mycobacterium avium pseudotuberculosis; how is it different from tuberculosis?

Answer 2

Granulomatous lymphangitis; NOT CASEOUS

Question 3

Key histo features of Y.pseudotuberculosis and Y.pestis

Answer 3

Necrotizing lesions with large bacterial colonies

Question 4

Clinical presentation of Y.pestis

Answer 4

Bubonic
Pneumonic
Septicemic

In cats and ferrets and prairie dogs

Question 5

Clinical presentation of Y.pseudotuberculosis

Answer 5

Gastrointestinal disease with lymphadenitis

In rodents and birds, occasionally cats

Question 6

Key virulence factors of corynebacterium pseudotuberculosis

Answer 6

1. Leukotoxic surface lipid- mycolic acid, induces inflammation and prevents phagolysosome
2. Exotoxin- phospholipase D, increases vascular permeability

Question 7

Key histo with Actinobacillus lignieresii

Answer 7

Pyogranulomatous inflammation around colonies of bacteria with Splendore Hoeppli material (sulfur granules); mineral

Question 8

Key histo with Francisella tularensis

Answer 8

A ton of necrosis and miliary abscesses in liver, spleen, LN, WITHOUT COLONIES (unlike Y pestis)

Question 9

Key histo with Bartonella henselae

Answer 9

Lymphoid hyperplasia, pyogranulomatous inflammation, myocarditis and VVE

Question 10

Key histo with Neorickettsia helminthoeca

Answer 10

Lymphoid depletion with histiocytosis of lymphoid organs; pleomorphic organisms in macrophages; adult trematoids in intestines

Question 11

Key histo with Sporothrix schenckii

Answer 11

Pyogranulomatous inflammation and intrahistiocytic or extracellular cigar shaped yeast