Entamoeba Flashcards
Entamoeba histolytica was first described by
Lambl
described amoebic liver
abscess
Councilman and lafleur in 1981
differentiated pathogenic and
nonpathogenic types of Amoebae
Schauudinn in 1903
established it pathogenic nature in 1875 in a dysenteric patient is St.Petersberg
Losch
is a disease caused by a
one-celled parasite called Entamoeba histolytica
Amebiasis
What is the cause of Entamoeba Histolytica
Amebiasis
What is the geographical Distribution of E Histolytica
Cosmopolitan
What is the habitat of E histolytica
Caecum and sigmoidal region of a man
What is the Infective stage of E histolytica
Quadrinucleate Cyst
How many nucleus are present in the precyst stage in the e histolytica
One
How many nuclei are there present in cyst stage in E histolytica
4 in mature
glycogen mass and chromatoidal bodies in Immature cyst
Trophozoites produce histolytic enzyme that produce necrosis of mucosa leading to the formation of
Flask shaped ulcer
Fever, diarrhea, dysenterym abdominal pain, localized
abdominal tenderness, tenesmus & strain, painful spasm
of anal sphincter (indicates rectal ulceration)
Acute Intestinal Amoebiasis Colitis
Recurrent attacks of dysentery with intervening periods of constipation, abdominal distension & flatulence, weight loss and cachexia
Chronic Intestinal Amoebiasis
Rare progressive disease of high mortality (high fever-severe bloody diarrhea - diffuse tenderness -
peritonitis)
Fulminating Colitis
Amoebic hepatitis or amoebic abscess, lung abscess, brain abscess or skin abscess
Extra Intestinal Amoebiasis
What is the treatment in killing amoebiasis in the wall of the intestines, blood, liver abscesses
Metronidazole, tinidazole (Tissue amoebicide)
What is the treatment in killing trophozoites and the cyst in the lumen of the intestines
Diluxanide furoate (Luminal Amoebicide)
-formerly designated as non-pathogenic E.histolytica
-9x more prevalent than E.histolytica
-Morphologically identical with E.histolytical
- Their DNa and ribosomal RNA are different
- microscopic identification - unreliable
- Dx - negative serologic tests
-Trophozoites will have no ingested RBC
Entamoeba Dispar
Morphologically indistinguishable from E. histolytica/E.dispar
Entamoeba Hartmanni
Most common endocommensal of humans
Entamoeba Coli
Describe the cytoplasm of E Coli
Dirty Looking or honeycomb Appearance
A common inhabitant of the mouth of man
E Gingivalis
Second most common endocommensal of humans
Endolimax Nana
