Energy Production: Carbs S2L1 Flashcards
1
Q
What is pyruvate converted to before entering stage 3?
A
Acetyl CoA
2
Q
What enzyme converts pyruvate to acetyl CoA before entering the TCA?
A
Pyruvate dehydrogenase
3
Q
Why is the conversion of pyruvate to acetyl CoA sensitive to vitamin B1 deficiency?
A
PDH requires various co factors such as FAD, thiamine, pyrophosphate and lipoic acid which are all provided by B vitamins
4
Q
What does PDH deficiency lead to and why?
A
Lactic acidosis - accumulation of pyruvate which has to be converted to lactate
5
Q
What does acetyl CoA enter in stage 3 of metabolism?
A
Tricarboxylic acid cycle (TCA)
6
Q
What are the products from one molecule of glucose in the TCA?
A
6 NADH
2 FADH2
2 GTP
7
Q
What metabolic reaction is glycolysis and the TCA?
A
Substrate level phosphorylation
