Endothelium

Question 1

Endothelium function

Inflammation

Answer 1

Physical lining that blood cells do not normally adhere to

Captures leukocyte to fight infection

Question 2

Infection and endothelium

Answer 2

Express chemoattractants
Capture leukocytes
Rolling/slow rolling
adhesion
Into endothelium to fight

Question 3

Inflammation

Redness and heat

Swelling

Leukocyte capture

Answer 3

Redness/heat/swell/pain

Due to VD, as mediators stimulate endothelium to secrete NO

Large gaps in endothelium- lose H2O and AB

Vasc endothelium inserts molecules into membrane, causing migration

Question 4

Endothelium as permeability barrier

Secrete paracrine agents

Answer 4

Exchange nutrients, met prodcts, fluid

Regulate transport

Act on SM cells
VD- PGI2
VC- endothelin

Question 5

Mechanisms
PGI2
NO
EDHF

Answer 5

Comes from AA and COX, activates AC, cAMP= relax

Comes from L arg, cGMP release= relax

hyperpolarize and relax

Question 6

NO production

Answer 6

agonists bind receptor, inc cytosolic Ca

Shear stress by inc BF activates eNOS

Question 7

Without NO

Viagra effect

Answer 7

significantly dec BF

Inhibit cGMP breakdown, inc NO actions on target cell

Question 8

Endothelium other functions

Answer 8

Mediates angiogenesis
Vascular remodeling
Form/maintain ECM
Produce GF
Secrete clotting substances
Secrete cytokines

Question 9

Dz with endothelial dysfunction

Answer 9

HTN
Obesity
Dyslipid
DM
HF
Athero
Smoking
Aging
Vasc injury