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Drugs > Endoparacitiides > Flashcards

Endoparacitiides Flashcards

1
Q

8 classes of pre-2000 Endoparaciticides

A

Organophsophatates
Benzimidazole
Salicylanilides
Pyrazinoisoquinolones
Sulphonamides
Tetrahydropyramidines/ imidazothiazoles
Hexahydropyrazine
Macrolytic lactones

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2
Q

3 post-2000 endoparasitics

A

Cyclic Octadepsipeptide
Aminoacetonitrile derivative
Spioinidole

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3
Q

3 examples of organophosphates

A

Dichlorvos
Haloxon
Naphalofos

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4
Q

8 examples of Benzimidazoles

A
  1. Albendazole
  2. Febantel
  3. Fenbendazole
  4. Flubendazole
  5. Mebendazole
  6. Oxfendazole
  7. Oxibendazole
  8. Thiabendazole
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5
Q

Target and action of bendizamadole

A

Bind to B-tubulin
- inhibition/blockage of polymerization (assembly of dimers)
-> abnormal microtubule formation and disrupts intracellular homeostasis and energy metabolism

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6
Q

2 examples of salicyanilides

A

Closantel
Rafoxanide

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7
Q

2 examples of pyrazinoisoquinolones

A

Praziquantel
Epsiprantel

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8
Q

Example of sulphonamide

A

Clorsulon

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9
Q

Example of Tertrahydropryamidines/imidazothiazole

A

Levamisole
Morantel
Pyrantel
Oxantel

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10
Q

Action of tetrahydropyridines/imidazothiazoles

A

Excitatory to the Nicotinic acetylcholine receptor
-> contraction-> spastic paralysis of the worms

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11
Q

2 Examples of Hexahydropyrazine

A

piperazine and its derivative diethycarbamazine

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12
Q

7 examples of macrolytic lactones

A

abamectin
Doramectin
Eprinomectin
Ivermectin
Moxidectin
Milbemycin oxime
Selamectin

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13
Q

Target and action of macrocytic lactones

A

Target: GABA receptor and glutamate-gated chloride channel
Action: Flaccid paralysis of worms, GABA and Glutamate are inhibitory

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14
Q

2 examples of cyclic octadepsipeptide

A

Nitroxynil
Emodepside

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15
Q

Action of cyclic octadespitpetide

A

Acts on specific class of transmembrane G-protein coupled receptors (GPCRs, desiphillins)
Iatrophillin receptor class

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16
Q

Example and action of aminoacetonitrile derivative

A

Monepental

MPTL-1 receptors, a unique kind of Ach receptor

17
Q

Anthelmintic resistance

A

Drugs (6 decks)

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