Endometrial cancer staging

Question 1

Stage IA

Answer 1

IA1: Non aggressive histology limited to polyp or confined to endometrium
IA2: Non aggressive histology with <50% MI w/ no or focal LVSI
IA3: Low grade limited to uterus and ovary (<50% MI, no or focal LVSI, absence of additional mets, unilateral ovary w/o capsule involvement)

Question 2

Stage IB

Answer 2

Non aggressive histology with ≥50% MI, and no or focal LVSI

Question 3

Stage IC

Answer 3

Aggressive histology limited to polyp or confined to endometrium

Question 4

Stage II

Answer 4

IIA: invasion of cervical stroma of non aggressive histology
IIB: substantial LVSI of non aggressive histiology
IIC: Aggressive histology with any MI

Question 5

Stage IIIA

Answer 5

IIIA1: spread to ovary or tube (except when meeting IA3 criteria)
IIIA2: Involves uterine subserosa or spread through the serosa

Question 6

Stage IIIB

Answer 6

IIIB1: mets or direct spread to vagina and/or parametria
IIIB2: mets to pelvic peritoneum

Question 7

Stage IIIC

Answer 7

IIIC1i: pelvic micromets
IIICii: pelvic macromets

IIIC2i: PA micromets
IIIC2ii: PA macromets

Micromet: 0.2-2mm
Macromet: >2mm

Question 8

Stage IV

Answer 8

IVA: invasion of bladder mucosa and/or intestinal bowe/mucosa
IVB: abdominal peritoneal mets beyond the pelvis
IVC: Distant mets to any extra- or intra-abdominal LN above the renal vessels, lungs, liver, brain, or bone