Endocrinology Flashcards
what is the function of insulin?
reduces hepatic glucose production
increases skeletal muscle and adipose tissue glucose uptake
reduces glycogenolysis and gluconeogenesis
direct inhibition of glucagon secretion
inhibition of glucagon gene in pancreatic alpha cells
what are the most serious complications of diabetes?
diabetic ketoacidosis
hyperosmolar hyperglycaemic syndrome
what are the investigations and results required to diagnose DKA?
existing diabetes
or
new presentation with BM >11.1mmol/L
urinary ketones >++
or
capillary ketones >3.0mmol/L
venous pH <7.30
and/or
bicarbonate <15mmol/L
name some hyperglycaemic states
DM
HHS
stress hyperglycaemia
impaired glucose tolerance
name some ketotic states
ketotic hyperglycaemia
alcoholic ketosis
starvation ketosis
(not always harmful)
name some metabolic acidotic states
lactic acidosis hyperchloraemic acidosis salicylism uraemic acidosis drug-induced acidosis
what are the signs of insulin reduction?
total body K depletion PO4 decrease Cr increase renal failure ketoacidosis hyperlipidaemia glycogenolysis gluconeogenesis hyperglycaemia hyperosmolarity glucosuria
what is the pathogenesis of DKA?
absolute insulin deficiency gluconeogenesis, glucogenolysis and hyperglycaemia -> osmotic diuresis electrolyte abnormalities dehydration hormone sensitive lipase production increased FFA to liver increased ketogenesis acidosis
what is the pathogenesis of HHS?
relative insulin deficiency gluconeogenesis, glucogenolysis and hyperglycaemia -> osmotic diuresis electrolyte abnormalities dehydration hyperosmolarity increased hormone sensitive lipase absent or minimal ketogenesis
what are the precipitants of a DKA?
newly diagnosed diabetes non-compliance omission pump failure infection inflammation iatrogenic infarction intoxication
what are the symptoms of DKA?
deep, rapid breathing (dyspnoea) fruity-smelling breath dry mouth nausea vomiting abdominal pain lethargy polyuria polydipsia new diagnosis/symptoms of T1DM develops over <1 day
what are the symptoms of HHS?
polyuria +/- polydipsia weight loss confusion lethargy develops over >1 day
what is the management of DKA?
ABC IV fluids (1L 0.9% NaCl over 1 hour) insulin potassium treat cause reassess prevention of future DKA
what are the differences in managing DKA <18yrs?
fluid prescription based on estimated weight and estimated deficit
insulin not started until IV fluids running for 1 hour
use 0.9% NaCl with 5% glucose
describe the insulin infusion in a DKA
0.1 units/kg/hour (7 units in 70kg)
draw up 50 units Actrapid
add to 49.5ml 0.9% NaCl in a 50ml syringe
concentration 1 unit/ml
continue long-acting insulin (lantis, levemir)
what is the management of hyper/hypokalaemia post DKA?
> 5.5mmol/L nil
3.5-5.5mmol/L requires 40mmol/L replacement of infusion solution
<3.5mmol/L requires senior review
what are the causes of a DKA?
gastroenteritis UTI pneumonia MI stroke pancreatitis non-compliance cocaine first presentation
what is involved in the reassessment of a DKA?
GCS
clinical observations
hourly CBG and ketones
once CBG <14mmol/L start 10% dextrose alongside 0.9% NaCl
high rate insulin infusion until ketones are clear
once ketones <0.6mmol/L, resume s/c insulin if able to eat and drink, fasting protocol with variable rate insulin if not
what are the complications of DKA?
infection shock vascular thrombosis pulmonary oedema cerebral oedema (mannitol)
what is the treatment of HHS?
hydration treat underlying cause insulin drip after aggressive hydration switch to s/c regimen once glucose <11mmol/L and patient eating K replacement
describe the effects of SGLT2 inhibitors
glucosuria free fatty acid release pancreatic glucagon secretion hepatic glucose production and ketogenesis renal ketone resorption
what is the definition and causes of gluconeogenesis?
delivery of precursors to liver from breakdown of fat and muscle
insulin deficiency
glucagon excess
define hypoglycaemia
blood glucose <3.9mmol/L
what are the symptoms of hypoglycaemia?
sweating palpitations agitation shaking hunger confusion drowsiness speech difficulty odd behaviour incoordination
what are the risk factors for hypoglycaemia?
intensive treatment missed meal PMHx severe hypo hypo unawareness duration of diabetes increased age exercise pregnancy lipoatrophy/hypertrophy reduced clearance (renal failure, SUs, ACEis, ARBs)
what is the management of mild hypoglycaemia?
15-20g quick-acting carbohydrate
or
150-200ml pure fruit juice
test glucose level 15 minutes later and if <4.0mmol/L repeat up to 3 times
what is the management of moderate hypoglycaemia?
1.5-2 tubes of 40% glucose gel
or
1mg glucagon IM
test glucose level 15 minutes later and if <4.0mmol/L repeat up to 3 times
what is the management of severe hypoglycaemia?
ABC stop IV insulin 75ml 20% IV glucose over 15 minutes or 1mg glucagon IM check glucose after 10 minutes and repeat if <4.0mmol/L
in what conditions will glucagon not be effective?
malnourishment
severe liver disease
repeated hypoglycaemia
describe the hypothalamic-pituitary-thyroid axis
hypothalamus produces TRH which acts on the pituitary
pituitary produces TSH which acts on the thyroid
thyroid produces T3 and T4 which acts on the heart, liver, bone and CNS
what are the TFT results for primary hypo/hyperthyroidism?
hypo - FT4 low, TSH high
hyper - FT4 high, TSH low
what are the TFT results for secondary hypo/hyperthyroidism?
hypo - FT4 low, TSH low/normal
hyper - FT4 high, TSH high/normal
what are the symptoms and signs of hypothyroidism?
tiredness weight gain cold intolerance, cold peripheries, hypothermia goitre (deep voice) depression poor memory dry hair and skin myalgia, myotonia constipation periorbital oedema deafness hypertension HF bradycardia pericardial effusion anaemia
what are the causes of hypothyroidism?
agenesis Hashimoto's disease (autoimmune) thyroiditis iodine deficiency antithyroid drugs lithium amiodarone monoclonal antibody therapy pituitary adenoma following pituitary surgery
what is the treatment of hypothyroidism and what adjustments does this require in special situations?
thyroxine
1.6 mcg/kg
reduced dose with cardiac history, elderly
assess response after 6-8 weeks
what are the symptoms and signs of hyperthyroidism?
weight loss irritability itching heat intolerance tremor thirst vomiting diarrhoea oligomenorrhoea hyperkinese tachycardia or AF full pulse warm vasodilated peripheries exophthalmos lid lag goitre bruit
what are the causes of hyperthyroidism?
grave's disease (autoimmune) toxic multi nodular goitre toxic nodule (solitary) thyroiditis (viral, autoimmune, postpartum) gestational thyrotoxicosis exogenous iodine amiodarone monoclonal antibody therapy excess T4 TSH secreting pituitary adenoma HCG producing tumours
describe the pathology and symptoms of Grave’s disease
autoimmune
presence of stimulating TSH receptor antibodies
thyroid eye disease (specific to Grave’s)
swelling and inflammation of retro-orbital tissues and extra ocular muscles; proptosis
gritty sensation in eye
lid lag
periorbital oedema
optic nerve compression (severe disease)
what is the treatment of hyperthyroidism?
anti-thyroid drugs (carbimazole)
radioactive iodine therapy
surgery
what are the side effects of carbimazole and prophythiouracil (PTU)?
rash
agranulocytosis (stop if develop a sore throat or fever and require surgery WCC measurement)
liver dysfunction (PTU)
describe the 2 regimens of anti-thyroid treatment and why/when they are used
titration - high dose anti-thyroid and titrate down as TFT improve, used in women planning pregnancy
block and replace - high dose carbimazole and replace with thyroxine, requires less monitoring
what are the causes of goitres/nodules?
puberty pregnancy grave's hashimoto's thyroiditis iodine deficiency multi nodular goitre solitary nodular cysts tumours
what are the types of thyroid cancer?
papillary follicular medullary cell anaplastic lymphoma
what investigations should be performed on a thyroid lump?
TFT thyroid antibodies US thyroid FNA CT thoracic inlet
what is the treatment of thyroid cancer?
surgery (lobectomy or total thyroidectomy) ablative radioactive iodine high dose thyroxine (suppress TSH) radiotherapy chemotherapy
what hormones are produced by the different regions of the adrenal cortex and medulla?
zona glomerulosa - aldosterone
zona fasciculata - cortisol
zona reticularis - adrenal androgens
medulla - catecholamines
how do ACTH and RAAS affect the adrenal cortex?
cause the production of cortisol and aldosterone (glucocorticoids and mineralocorticoids)
what are the symptoms and signs of Cushing’s syndrome?
weight gain slow healing of cuts increased infection risk fatigue glucose intolerance sweating moon face buffalo hump skin thinning depression, irritability hypertension oligomenorrhoea/erectile dysfunction
what are the causes of Cushing’s syndrome?
ACTH dependent;
pituitary adenoma
ectopic ACTH
ACTH independent;
exogenous steroids
adrenal adenoma/hyperplasia
what investigations are required to diagnose Cushing’s syndrome?
24hr urinary free cortisol
48hr low dose dexamethasone suppression test
what is the treatment of Cushing’s syndrome?
treat the cause
transsphenoidal resection of pituitary tumour
surgical resection of adrenal tumour
weaning and discontinuation of exogenous steroid
in pituitary or adrenal surgery require steroid cover (IM then oral)
define Addison’s disease
an absolute or relative lack of adrenal (endocrine) function
what are the symptoms and signs of Addison’s disease?
fatigue weakness weight loss nausea vomiting abdominal pain diarrhoea constipation myalgia decreased libido amenorrhoea hyperpigmentation hypotension axillary and pubic hair thinning vitiligo
what are the causes of primary adrenal insufficiency?
autoimmune TB metastatic disease trauma opportunistic infection bilateral adrenal haemorrhage/infarction anticoagulant therapy coagulopathy postoperative state severe sepsis
what are the causes of secondary/tertiary adrenal insufficiency?
panhypopituitarism
isolated ACTH deficiency
traumatic brain injury
high dose glucocorticoids
what is the treatment of adrenal insufficiency?
hydrocortisone 15mg morning and 5mg afternoon (glucocorticoid)
rarely prednisolone 5mg or dexamethasone 0.5mg
fludrocortisone 100mcg daily (mineralocorticoid), only required in primary disease