Endocrine Therapy

Question 1

which hormone is produced in the pituitary gland?

Answer 1

LH

Question 2

Estrogen receptor primarily binds estrogen where in the cell?

Answer 2

In the cytoplasm

Question 3

Which enzyme converts androstenedione to estrone?

Answer 3

CYP19

Question 4

Tamoxifen class and use

Answer 4

SERM (has both agonist and antagonist effects)
Can be used for ER+/PR+ breast cancer in both pre and post menopausal women, can be used for prevention

Question 5

Fulvestrant Class and Use

Answer 5

SERD (full antagonist)
Can be used for ER+ metastatic breast cancer in post-menopausal women only

Question 6

Aromatase

Answer 6

CYP19 = Converts androstenedione and testosterone to estrone and estradiol

Question 7

Where do aromatase inhibitors target?

Answer 7

peripheral adipose tissue

Question 8

anastrazole and letrozole class and use

Answer 8

aromatase (CYP 19 inhibitor) used in post-menopausal women ER+ cancer

Question 9

Exemestane class and use

Answer 9

steroidal aromatase inhibitor (CYP 19 inhibitor), Post-menopausal women with ER+ breast cancer

Question 10

Which compound directly inhibits the activity of the estrogen receptor throughout the body?

Answer 10

SERD– fulvestrant

Question 11

Which compound acts directly on AR?

Answer 11

enzalutamide