Endocrine System (Exam Two) Flashcards
How does Adrenocorticotropic Hormone (ACTH) work?
- Stimulates the adrenal cortex to release glucocorticoids (cortisol)
- Acts on the adrenal gland
The Adrenal Medulla releases what hormones?
HINT: MEN
Epinephrine and Norepinephrine
What effect do Epinephrine and Norepinephrine have on the body?
- Act on alpha one, beta one and beta two receptors
- Increase the heart rate, increase the force of cardiac contraction, bronchodilation, vasoconstriction of peripheral arteries, vasodilates skeletal muscle arterioles, tells the liver to convert glycogen to glucose for energy (increased blood sugar)
When are Epinephrine and Norepinephrine released?
Released during stressful times (flight or fight) to manage stress response and keep body safe
The Adrenal Cortex releases what hormones?
It releases corticosteroids, which include:
- Glucocorticoids (Cortisol)
- Mineralocorticoids (Aldosterone)
- Gonadocorticoids (Androgens)
What two hormones secreted by the adrenal cortex are essential for life?
- Glucocorticoids (Cortisol)
- Mineralocorticoids (Aldosterone)
What tropic hormone is released to promote the release of Cortisol from the Adrenal Cortex?
Adrenocorticotropic Hormone (ACTH)
What is the target organ of Mineralocorticoids (Aldosterone)?
Kidneys
What body systems are affected by Glucocorticoids (Cortisol)?
All of them
What does Glucocorticoids (Cortisol) do for the body?
Provides energy sources to the body during stress (because it tells the liver to convert glycogen to glucose)
What organ is both an endocrine and exocrine gland?
Pancreas
What hormones does the Pancreas synthesize and release?
- Insulin
- Glucagon
Where do beta and alpha cells live within the Pancreas?
Islet of Langerhans
What are the three causes of endocrine disorders?
- Overproduction of hormones
- Underproduction of hormones
- Side effects of certain drugs
What is a primary endocrine disorder?
Something is wrong with the actual gland
What is a secondary endocrine disorder?
- Problems outside of the gland
- Something is wrong with a different gland or organ
What does Mineralocorticoids (Aldosterone) do for the body?
-Regulates sodium and potassium balance
What is Cushing Syndrome?
- Hypersecretion of cortisol levels in the blood
- Can affect aldosterone and androgens
What causes Cushing Syndrome?
- Chronic exposure to excess corticosteroids
- Exogenous corticosteroid administration
What is Cushing Disease?
- Specific type of Cushing Syndrome
- Hypersecretion of cortisol throughout the day regardless of time/event
What are the two types of Cushing Disease? What causes them?
- Pituitary Cushing Disease is caused by hypersecretion of ACTH in pituitary gland causing adrenal gland to secret too much cortisol
- Adrenal Cushing Disease is caused by problem in the adrenal cortex (only involves one adrenal gland)
Is Cushing Syndrome or Cushing Disease more prevalent?
Cushing Syndrome
What are the signs and symptoms of Cushing Syndrome?
- Weight gain
- Truncal/generalized obesity
- Thin arms and legs
- Moon face
- Buffalo Hump
- Muscle wasting/weakness
- Hyperglycemia
- Type II Diabetes
- Osteoporosis
- Loss of collagen (i.e. striae, wrinkles)
- Immunosuppression
- Increased risk for infection
- Irritability, anxiety, euphoria, psychosis
What causes a moon face and buffalo hump in patients with Cushing Syndrome?
Excess deposit of adipose tissue