Endocrine Secondary Messengers Flashcards
Dopamine
Gi in Lactotrophs
Variety of G-pcrs elsewhere.
Prolactin
Tyrosine Kinase
ADH
V1 Receptors: Gq
V2 Receptors: Gs
Oxytocin
Gq in Uterine Smooth Muscle
GHRH (Growth Hormone Releasing Hormone)
Gs in Somatotrophs
Somatostatin (Growth Hormone Inhibiting Hormone)
Gi in Somatotrophs
Growth Hormone
Tyrosine Kinase
Serotonin (5-Hydroxytryptamine)
Variety of G-pcrs
Also Ligand-gated ion channels
T3 (active Thyroid Hormone)
Intracellular Receptor
Aldosterone
Intracellular Receptor
Cortisol
Intracellular Receptor
Androgens (DHEA, Androstenedione, Testosterone, Dihydrotestosterone, Estradiol)
Intracellular Receptor
Angiotensin II
Gq in Zona Glomerulosa
ACTH
Gs in Zona Reticularis and Zona Fasciculata
CRH (Corticotropin Releasing Hormone)
Gs in Corticotropes
Acetylcholine (in Adrenal Medulla)
Ligand gated sodium channels
TRH (Thyroid Releasing Hormone)
Gq in Thyrotrophs
TSH
Gs in Thyroid follicular cells
Glucagon
Gs in target tissues
Insulin
Tyrosine Kinase
Ca 2+
Gq in Parathyroid Chief Cells
PTH
Unclear? in Osteoblasts
Gs in Proximal Tubule Cells
Vitamin D3
Intracellular Receptor
GnRH (Gonadotropin Releasing Hormone)
Gq in Gonadotrophs
LH
Gs in Leydig Cells of Testes
FSH
Gs in Sertoli Cells of Testes