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BPM2 > DM Medications & Toxins > Flashcards

DM Medications & Toxins Flashcards

1
Q

Saproterin

A

Structural analogue of BH4.

Used to treat PKU II (deficiency of BH4 synthesis or BH2-reductase)

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2
Q

Orlistat

A

Pancreatic lipase inhibitor.

Weight loss drug

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3
Q

Nitisinone

A

Inhibits 4-OH-Phenylpyruvate dioxygenase (PDO)

Used to treat Tyrosinemia Type 1 (Tyrosinosis)

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4
Q

Acetadote (N-acetyl cysteine)

A

Binds NAPQI and helps replenish glutathione

Used to treat acetaminophen overdose

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5
Q

Antabuse (Disulfuram)

A

Inhibits aldehyde dehydrogenase

Historically used to treat alcohol dependence by causing higher levels of aldehyde when drinking –> stronger hangover symptoms

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6
Q

Isoniazid

A

TB medication

Inactivates pyridoxine as a side effect- B6 supplements need to be given with this medication to prevent PLP deficiency.

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7
Q

Amytal

A

Barbiturate

Inhibits Complex 1 of ETC

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8
Q

Rotenone

A

Insecticide

Inhibits Complex 1 of ETC

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9
Q

Piercidin A

A

Bacterial Antibiotic

Inhibits Complex 1 of ETC

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10
Q

Antimycin A

A

Antibiotic

Inhibits Complex 3 of ETC

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11
Q

Cyanide

A

Inhibits Complex 4 of ETC

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12
Q

Azide

A

Inhibits Complex 4 of ETC

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13
Q

Hydrogen Sulfide

A

Inhibits Complex 4 of ETC

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14
Q

Carbon monoxide

A

Inhibits Complex 4 of ETC

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15
Q

Oligomycin

A

Antiobiotic

Inhibits ATP Synthase

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16
Q

Atractyloside

A

Toxic glycoside from plant

Inhibits ATP/ADP antiporter in inner mitochondrial membrane by binding the inter-membrane space facing portion (outward).

Similar effect to Oligomycin

17
Q

Bongkrekic Acid

A

Toxin from contaminated coconuts

Inhibits ATP/ADP antiporter in inner mitochondrial membrane by binding the matrix facing portion (inward)

Similar effect to Oligomycin

18
Q

DNP (2,4-dinitrophenol)

A

Synthetic uncoupler of ETC

19
Q

Aspirin (ASA)

A

Synthetic uncoupler of ETC

20
Q

Gramicidin

A

Channel forming ionophore

Uncouples ETC

21
Q

Valinomycin

A

Mobile carrier, makes inner membrane permeable to K+

Uncouples ETC

22
Q

UCP1 (thermogenin)

A

Protein

Purposefully uncouples ETC for thermogenesis

BPM2 (6 decks)

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