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Pharmacology II > Endocrine Quiz > Flashcards

Endocrine Quiz Flashcards

1
Q

Replacement therapy in hypothyroidism:
I. PTU
II. Strong iodine solution
III. Levothyroxine
IV. Liotrix

I & ll only
III & IV only
Il & Ill only
I & III only

A

III & IV only

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2
Q

The only isotope used for the treatment of thyrotoxicosis:

Potassium iodide
131I
Lugol solution
PTU

A

131I

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3
Q

In comparing levothyroxine and liothyronine, which of the following statements is not correct?

•Both levothyroxine and liothyronine are naturally occuring thyroid hormones
•Liothyronine can be converted in the peripheral circulation to levothyroxine
•Liothyronine is more potent than levothyroxine
•The plasma concentration of liothyronine is less than that of levothyroxine

A

•Both levothyroxine and liothyronine are naturally occuring thyroid hormones

(Because they are SYNTHETIC PREPARATIONS)

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4
Q

An end state of untreated hypothyroidism:

Grave’s disease
Thyroid storm
Myxedema coma
Neoplasms of the thyroid

A

Myxedema coma

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5
Q

Which of the following conditions is associated with hyperthyroidism and best given with antithyroid agents?

Myxedema
Hashimoto’s thyroiditis
Myxedema & CAD
Grave’s disease

A

Grave’s disease

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6
Q

Enzyme responsible for the oxidation of iodide in the synthesis:

5’deiodinase
Thyroid peroxidase
Thyroid oxidase
Transpeptidase

A

Thyroid peroxidase

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7
Q

Thyroid hormone secretion and transport are controlled by:

FSH
TSH
LH
TRH

A

TSH

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8
Q

Management of thyroid carcinoma includes the following:
I. Lifetime levothyroxine
Il. Radioiodine therapy
lll. Total thyroidectomy
IV. Methimazole

II & III only
I, II, IV only
Il, II & IV only
I, II & III only

A

I, II & III only

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9
Q

Levothyroxine is classified as:

Antithyroid
lodides
Thyroid replacement hormone agent
Thibamides

A

Thyroid replacement hormone agent

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10
Q

Management for ophthalmopathy includes the following:
I. Total surgical excision
II. Smoking cessation
III. Prednisone
IV. Levothyroxine

II & III only
Il, III & IV only
I, II & III only
I, III & IV only

A

I, II & III only

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11
Q

The major product of thyroid gland:

Thyroxine
T3
Calcitonin
Cortisone

A

Thyroxine

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12
Q

An anterior pituitary hormone which resembles the structure of prolactin.

GH
FSH
LH
ACTH

A

GH

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13
Q

Drug of choice for endometriosis:

Menatropins
Bromocriptine
Oxytocin
Leuprolide

A

Leuprolide

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14
Q

Dimeric proteins that activates G-protein coupled receptors:
I. FSH
Il. PRL
lll. LH
IV. TSH

l & ll only
l, ll & lll only
l, lII & IV only
II, III & IV only

A

l, lII & IV only

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15
Q

Both oxytocin and vasopressin increase:

•Constriction of coronary blood vessels, thereby reducing cardiac output
•Uterine contractility
•Water reabsorption with equal effectiveness in diabetes insipidus.
•Constriction of uterine blood vessels.

A

Water reabsorption with equal effectiveness in diabetes insipidus.

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16
Q

Drug of choice for acromegaly:

GH
GH receptor antagonist
Vasopressin receptor agonist
Oxytocin receptor antagonist

A

GH receptor antagonist

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17
Q

Single-chain protein hormones with significant homology which activate receptors of the JAK/STAT superfamily.
I . ACTH
Il. PRL
III. TSH
IV. GH

I & II only
III & IV only
I & III only
II & IV only

A

II & IV only

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18
Q

A peptide cleaved from a larger precursor proopiomelanocortin and acts through G-protein coupled receptor.

TSH
FSH
LH
ACTH

A

ACTH

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19
Q

Known as menopausal gonadotropins which mimics the effects of endogenous LH:

Menotropins
Bromocriptine
Octreotide
Desmopressin

A

Menotropins

20
Q

Which of these drugs is used for the treatment of diabetes insipidus?

Calcitonin
Strong iodine
Bromocriptine
Desmopressin

A

Desmopressin

21
Q

Posterior pituitary hormones:
I. Vasopressin
II. GH
III. Cortisone
IV. Oxytocin

I & ll only
lII & IV only
II & III only
I & IV only

A

I & IV only

22
Q

A recombinant form of human insulin-like growth factor 1 used for long-term treatment of growth failure in children with severe primary IGF-1 deficiency.

Octreotide
Mecasermin
Lantreotide
Pegvisomant

A

Mecasermin

23
Q

GnRH receptor antagonist approved for use in men with advanced prostate cancer.
I. Ganirelix
II. Degarelix
III. Abarelix
IV. Cetrorelix

I & ll only
II & III only
III & IV only
I & IV only

A

II & III only

24
Q

Which of the following is/are natural estrogens?

Quinestrol
Estriol
Mestranol
Chlorotrianisene

A

Estriol

25
Q

Which of the following drug is used for postmenopausal osteoporosis?

Clomiphene
Danazol
Raloxifene
Mifeprestone

A

Raloxifene

26
Q

The major excretory product of the ovary:

Estradiol
Estrone
Estriol
Mestranol

A

Estradiol

27
Q

Cholesterol is the the precursor of which of the following steroid hormones?
I. Glucocorticoids
II. Mineralocorticoids
III. Androgen
IV. Progestins

I & ll only
II & III only
I, II & III only
II, III & IV only

A

I, II & III only

28
Q

One of the most prolific natural source of estrogenic substances is from:

Pregnant mare
Pregnant women
Stallion
Sheep

A

Stallion

29
Q

Initiates and controls male sexual development and maintains the integrity of the male reproductive system:

Estrogen
Testosterone
Corticotropin
Insulin

A

Testosterone

30
Q

Used to induce ovulation:

Mifeprestone
Progesterone
Testosterone
Clomiphene

A

Clomiphene

31
Q

Which of the following substances when present in urine is the most likely positive sign of pregnancy:

FSH
hCG
TSH
ACTH

A

hCG

32
Q

The following are steroidal synthetic estrogens:
I. Mestranol
II. Chlorotrianisene
III. Ethinyl estradiol
IV. Diethylstilbestrol

I & II only
III & IV only
I & III only
II & IV only

A

I & III only

33
Q

The main estrogen during pregnancy:

Estradiol
Estrone
Estriol
Quinestrol

A

Estriol

34
Q

A natural compound derived from cottonseed which destroys elements of the seminiferous epithelium:

Cyproterone
Gossypol
Medroxyprogesterone
Danazol

A

Gossypol

35
Q

Intermediate-acting glucocorticoids, except:

Betamethasone
Triamcinolone
Fluprednisolone
Paramethasone

A

Betamethasone

36
Q

The newest of the steroid synthesis inhibitors approved for the treatment of refractory prostate cancer.

Metyrapone
Abiraterone
Mitotane
Spironolactone

A

Abiraterone

37
Q

Management for Cushing’s syndrome includes, except:

Irradiation
Hydrocortisone
Fludrocortisone
Surgery

A

Fludrocortisone

38
Q

Which of the following statement is/are true about corticosteroid?
I. Cortecosteroids act on the immune system.
II. It is used as replacement therapy when secretions of the pituitary or adrenal gland are deficient.
III. Corticosteroid therapy is not curative but used as a supportive therapy.
IV. Reduce swelling

II & III only
III & IV only
I, II, & IV only
I, II, III, IV

A

I, II, III, IV

39
Q

Therapeutic indications for the use of glucocorticoids in nonadrenal disorders:
I. Allergic conjunctivitis
II. Contact dermatitis
III. Lupus erythematosus
IV. Sepsis

I & II only
III & IV only
I, II, & III only
I, II, III, & IV

A

I, II, III, & IV

40
Q

Aldosterone antagonist used for the treatment of hypertension and heart failure:

Trilostane
Miteprestone
Drospirenone
Eplerenone

A

Eplerenone

41
Q

A mineralocorticoids used for the treatment of aldosteronism:

Cortisone
Prednisone
Methylprednisone
Fludrocortisone

A

Fludrocortisone

42
Q

This is the result of bilateral adrenal hyperplasia secondary to an ACTH-secreting pituitary adenoma.

Addison’s disease
Congenital adrenalhyperplasia
Cushing’s syndrome
Chrouses syndrome

A

Cushing’s syndrome

43
Q

These are therapeutic indications for the use of glucocorticoids, EXCEPT:

Inflammation
Hypocalcemia
Asthma
Arthritis

A

Hypocalcemia

44
Q

Effects of cortisol except:

Anti-inflammatory effect
Stimulates gluconeogenesis
Immunosuppressant effect
Vasodilation

A

Vasodilation

45
Q

Only parenteral medication available in the treatment of severe Cushing’s syndrome:

Ketoconazole
Aminoglutethimide
Metyrapone
Etomidate

A

Etomidate

Pharmacology II (8 decks)

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