Endocrine Quiz Flashcards by Marah Joy M. FLORES

Replacement therapy in hypothyroidism:
I. PTU
II. Strong iodine solution
III. Levothyroxine
IV. Liotrix

I & ll only
III & IV only
Il & Ill only
I & III only

III & IV only

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The only isotope used for the treatment of thyrotoxicosis:

Potassium iodide
131I
Lugol solution
PTU

131I

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In comparing levothyroxine and liothyronine, which of the following statements is not correct?

•Both levothyroxine and liothyronine are naturally occuring thyroid hormones
•Liothyronine can be converted in the peripheral circulation to levothyroxine
•Liothyronine is more potent than levothyroxine
•The plasma concentration of liothyronine is less than that of levothyroxine

•Both levothyroxine and liothyronine are naturally occuring thyroid hormones

(Because they are SYNTHETIC PREPARATIONS)

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An end state of untreated hypothyroidism:

Grave’s disease
Thyroid storm
Myxedema coma
Neoplasms of the thyroid

Myxedema coma

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Which of the following conditions is associated with hyperthyroidism and best given with antithyroid agents?

Myxedema
Hashimoto’s thyroiditis
Myxedema & CAD
Grave’s disease

Grave’s disease

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Enzyme responsible for the oxidation of iodide in the synthesis:

5’deiodinase
Thyroid peroxidase
Thyroid oxidase
Transpeptidase

Thyroid peroxidase

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Thyroid hormone secretion and transport are controlled by:

FSH
TSH
LH
TRH

TSH

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Management of thyroid carcinoma includes the following:
I. Lifetime levothyroxine
Il. Radioiodine therapy
lll. Total thyroidectomy
IV. Methimazole

II & III only
I, II, IV only
Il, II & IV only
I, II & III only

I, II & III only

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Levothyroxine is classified as:

Antithyroid
lodides
Thyroid replacement hormone agent
Thibamides

Thyroid replacement hormone agent

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Management for ophthalmopathy includes the following:
I. Total surgical excision
II. Smoking cessation
III. Prednisone
IV. Levothyroxine

II & III only
Il, III & IV only
I, II & III only
I, III & IV only

I, II & III only

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The major product of thyroid gland:

Thyroxine
T3
Calcitonin
Cortisone

Thyroxine

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An anterior pituitary hormone which resembles the structure of prolactin.

GH
FSH
LH
ACTH

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Drug of choice for endometriosis:

Menatropins
Bromocriptine
Oxytocin
Leuprolide

Leuprolide

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Dimeric proteins that activates G-protein coupled receptors:
I. FSH
Il. PRL
lll. LH
IV. TSH

l & ll only
l, ll & lll only
l, lII & IV only
II, III & IV only

l, lII & IV only

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Both oxytocin and vasopressin increase:

•Constriction of coronary blood vessels, thereby reducing cardiac output
•Uterine contractility
•Water reabsorption with equal effectiveness in diabetes insipidus.
•Constriction of uterine blood vessels.

Water reabsorption with equal effectiveness in diabetes insipidus.

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Drug of choice for acromegaly:

GH
GH receptor antagonist
Vasopressin receptor agonist
Oxytocin receptor antagonist

GH receptor antagonist

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Single-chain protein hormones with significant homology which activate receptors of the JAK/STAT superfamily.
I . ACTH
Il. PRL
III. TSH
IV. GH

I & II only
III & IV only
I & III only
II & IV only

II & IV only

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A peptide cleaved from a larger precursor proopiomelanocortin and acts through G-protein coupled receptor.

TSH
FSH
LH
ACTH

ACTH

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Known as menopausal gonadotropins which mimics the effects of endogenous LH:

Menotropins
Bromocriptine
Octreotide
Desmopressin

Menotropins

Which of these drugs is used for the treatment of diabetes insipidus?

Calcitonin
Strong iodine
Bromocriptine
Desmopressin

Desmopressin

Posterior pituitary hormones:
I. Vasopressin
II. GH
III. Cortisone
IV. Oxytocin

I & ll only
lII & IV only
II & III only
I & IV only

I & IV only

A recombinant form of human insulin-like growth factor 1 used for long-term treatment of growth failure in children with severe primary IGF-1 deficiency.

Octreotide
Mecasermin
Lantreotide
Pegvisomant

Mecasermin

GnRH receptor antagonist approved for use in men with advanced prostate cancer.
I. Ganirelix
II. Degarelix
III. Abarelix
IV. Cetrorelix

I & ll only
II & III only
III & IV only
I & IV only

II & III only

Which of the following is/are natural estrogens?

Quinestrol
Estriol
Mestranol
Chlorotrianisene

Estriol

Which of the following drug is used for postmenopausal osteoporosis? Clomiphene Danazol Raloxifene Mifeprestone

Raloxifene

The major excretory product of the ovary: Estradiol Estrone Estriol Mestranol

Estradiol

Cholesterol is the the precursor of which of the following steroid hormones? I. Glucocorticoids II. Mineralocorticoids III. Androgen IV. Progestins I & ll only II & III only I, II & III only II, III & IV only

I, II & III only

One of the most prolific natural source of estrogenic substances is from: Pregnant mare Pregnant women Stallion Sheep

Stallion

Initiates and controls male sexual development and maintains the integrity of the male reproductive system: Estrogen Testosterone Corticotropin Insulin

Testosterone

Used to induce ovulation: Mifeprestone Progesterone Testosterone Clomiphene

Clomiphene

Which of the following substances when present in urine is the most likely positive sign of pregnancy: FSH hCG TSH ACTH

hCG

The following are steroidal synthetic estrogens: I. Mestranol II. Chlorotrianisene III. Ethinyl estradiol IV. Diethylstilbestrol I & II only III & IV only I & III only II & IV only

I & III only

The main estrogen during pregnancy: Estradiol Estrone Estriol Quinestrol

Estriol

A natural compound derived from cottonseed which destroys elements of the seminiferous epithelium: Cyproterone Gossypol Medroxyprogesterone Danazol

Gossypol

Intermediate-acting glucocorticoids, except: Betamethasone Triamcinolone Fluprednisolone Paramethasone

Betamethasone

The newest of the steroid synthesis inhibitors approved for the treatment of refractory prostate cancer. Metyrapone Abiraterone Mitotane Spironolactone

Abiraterone

Management for Cushing's syndrome includes, except: Irradiation Hydrocortisone Fludrocortisone Surgery

Fludrocortisone

Which of the following statement is/are true about corticosteroid? I. Cortecosteroids act on the immune system. II. It is used as replacement therapy when secretions of the pituitary or adrenal gland are deficient. III. Corticosteroid therapy is not curative but used as a supportive therapy. IV. Reduce swelling II & III only III & IV only I, II, & IV only I, II, III, IV

I, II, III, IV

Therapeutic indications for the use of glucocorticoids in nonadrenal disorders: I. Allergic conjunctivitis II. Contact dermatitis III. Lupus erythematosus IV. Sepsis I & II only III & IV only I, II, & III only I, II, III, & IV

I, II, III, & IV

Aldosterone antagonist used for the treatment of hypertension and heart failure: Trilostane Miteprestone Drospirenone Eplerenone

Eplerenone

A mineralocorticoids used for the treatment of aldosteronism: Cortisone Prednisone Methylprednisone Fludrocortisone

Fludrocortisone

This is the result of bilateral adrenal hyperplasia secondary to an ACTH-secreting pituitary adenoma. Addison's disease Congenital adrenalhyperplasia Cushing's syndrome Chrouses syndrome

Cushing's syndrome

These are therapeutic indications for the use of glucocorticoids, EXCEPT: Inflammation Hypocalcemia Asthma Arthritis

Hypocalcemia

Effects of cortisol except: Anti-inflammatory effect Stimulates gluconeogenesis Immunosuppressant effect Vasodilation

Vasodilation

Only parenteral medication available in the treatment of severe Cushing's syndrome: Ketoconazole Aminoglutethimide Metyrapone Etomidate

Etomidate