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Pharmacology II > Cancer Chemotherapy Quiz > Flashcards

Cancer Chemotherapy Quiz Flashcards

1
Q

The following are combination of penicillin and beta lactamase inhibitors:

I. Amoxicillin + clavulanic acid
II. Ampicillin + sulbactam
III. Piperacillin+tazobactam
IV. Ceftazidime + avibactam

A

l, ll, lll only

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2
Q

The following are true about antibiotics:
1. Antibiotics can be used as preventive or therapeutically used for the treatment of secondary infection that may occur with viral disease.
II. Taking medication prescribed for another patient without obtaining medical case is another frequent misuse or abuse.
III. Antibiotics should be taken for the full prescribed course to ensure the suppression and destruction of all pathogens.
IV. Disappearance of the symptoms is an indication that infection has been adequately treated and medication can now be discontinued.

A

l ,ll, lll only

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3
Q

Pen G is administered through injection:

Pen G is not stable in gastric acid.
Its action is specific for staphylococcal infection.
Dosage is 500mg po)
It has a broad spectrum of activity

A

Pen G is not stable in gastric acid.

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4
Q

Lactam and thiozolidine:

Cephalosporins
Penicillins
Monobactams
Carbapenems

A

Penicillins

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5
Q

True or False:

Patients who are allergic to penicillin should be considered allergic to all penicillins

A

True

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6
Q

The first true antibiotics derived from a number of strains of common molds found in bread and fruit.

Cephalosporins
Penicillins
Polymyxin
Vancomycin

A

Penicillins

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7
Q

The following statements are true except:

Bacteriostatic agents cause the body fluids that are not isotonic to result in killing of bacteria.
Bactericidal agents can cause lysis of the cell by weakening the cell wall.
Bacteriostatic agents inhibit the synthesis of metabolites essential to bacteria.
Bacteriostatic static agents either causes death of the bacterial cell or
destruction of the cell.

A

?

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8
Q

The first penicillin developed and the drug of choice for treating many infections such as gonorrhoea and streptococcal infections:

Pen V
Methicillin
Amoxicillin
Pen G

A

Pen G

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9
Q

True or False:

Antibiotics are ineffective for the treatment of viral infections, but can be used with viral diseases when secondary infection are present.

A

True

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10
Q

True or False:

Altering the permeability of the cell membrane which results in leakage of essential metabolic substances of bacteria is the mechanism of action of bactericidal agent.

A

True

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11
Q

Bacterial cell wall:

I. It contains greater than or 10 layers of peptidoglycans in g(+) bacteria.
II. Beta lactam interrupts the terminal transpeptidation process within the bacterial cell wall.
III. Peptidoglycans are polysaccharides which contains sugar and amino acids that provides mechanical stability to bacterial cell
wall.
IV. Peptidoglycans maintains cell shape.

I only
Il & III only
I, ll, lll only
I, II, III, IV

A

I, II, III, IV

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12
Q

A highly nephrotoxic drug when used orally, obtained from the strain of Bacillus subtilis and used for the treatment of infections due to mixed bacterial flora in surface lesions of the skin or mucous membrane:

Bacitracin
Daptomycin
Fosfomycin
Telavancin

A

Bacitracin

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13
Q

This drug is the only available in their class, and are more resistant to hydrolysis by chromosomal beta lactamases:

Cefepime
Cefamandole
Cefixime
Cefdinir

A

Cefepime

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14
Q

The only first generation parenteral preparations which is still in general use:

Cefazolin
Cefonicid
Cefotaxime
Cifixime

A

Cefazolin

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15
Q

Combinations of this drug are used for the treatment of meningitis:

Ceftolozane-Tazobactam
Ceftazidime Avimactan
Ceftriaxone - Cefotaxime
Cefamandole- Cefuroxime

A

Ceftriaxone - Cefotaxime

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16
Q

Drug of choice for endocarditis caused by MRSA:

Teicoplanin
Vancomycin
Daptomycin
Fosfomycin

A

Vancomycin

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17
Q

An antibiotic produced by Streptomyces orchidaceous and the 2nd drug of choice for the treatment of tuberculosis:

Bcitracin
Cycloserine
Fosfomycin
Teicoplanin

A

Cycloserine

18
Q

These drugs have expanded g(-) bacteria and can cross the blood brain barrier:

1st generation cephalosporins
2nd generation cephalosporins
3rd generation cephalosporins
4th generation cephalosporins

A

3rd generation cephalosporins

19
Q

A novel cyclic lipopeptide fermentation product of S. roseosporus and an effective alternative for Vancomycin:

Fosfomycin
Teicoolanin
Daptomycin
Telavancin

A

Daptomycin

20
Q

Caution need to be exercised when prescribing a cephalosporin to a patient with which known allergy:

Peanuts
Seafoods
Chicken
Penicillin

A

Penicillin

21
Q

The process by which the drug slides between DNA base pairs & inhibits DNA synthesis:

DNA synthesis
Transpeptidation
Alkylation
Intercalation

A

Intercalation

22
Q

The following agents works through by affecting the microtubule, except:

Docetaxel
Vinblastine
Vincristine
Vinorelbine

A

Docetaxel

23
Q

Common side effects of patient receiving chemotherapy:

I. Hair loss
II. Nausea
III. Vomiting
IV. Diarrhea

A

I, ll, lll, lV

24
Q

Which of the following combination is the treatment of choice for stage III & stage IV ovarian cancer:

Paclitaxel & cisplatin
Carboplatin & paclitaxel
Cisplatin & nivolumab
Dacarbazine & Temozolomide

A

Carboplatin & paclitaxel

25
Q

The following type of cancer respond to hormonal manipulation:

I. Lung cancer
II. Gl cancer
III. Prostate cancer
IV. Breast cancer

A

lll and lV only

26
Q

It indicates the presence of distal metastases and classified as 0-for the absence and 1 for the presence of distant metastases:

T
N
M
Stage 0

A

M

27
Q

Tumors of connective tissue:

Osteosarcoma
Hodgkin’s disease
Non Hodgkin’s disease
Chronic myeloid leukemia

A

Osteosarcoma

28
Q

The following chemotherapy agents can be administered intrathecally, except:

Methotrexate
Cytarabine
Thiotepa
Vincristine

A

Vincristine

29
Q

The following drugs form DNA cross links, resulting in inhibition of

DNA synthesis and function:

I. Lomustine
II. Melphalan
III. Procarbazine
IV. Bendamustine

A

I, ll, & IV only

30
Q

Single agent for the treatment of brain cancer:

Carmustine
Lomustine
Temozolomide
Ipilimumab

A

Lomustine

31
Q

Definitive test for the presence of cancer cells:

I. Biopsy
II. Pathological examination of the biopsy
III. MRI
IV. CT Scan

A

I and ll only

32
Q

Therapy to eradicate any clinically undetectable disease & lower cell burden:

Palliative therapy
Miantenance
Consolidation
Remission of induction

A

Consolidation

33
Q

Most common acute toxicity when taking alkylating agents:

Myelosuppression
Nausea & vomiting
Diarrhea
CNS depression.

A

Nausea & vomiting

34
Q

Tumors of the lymphatic system:

Breast cancer
Breast cancer:
Acute myeloid leukemia
Hodgkin’s disease

A

Hodgkin’s disease

35
Q

Most widely used alkylating agents for chronic lymphocytic leukemia:

Pertuzumab & Tamoxifen
Trastuzumab & Tamoxifen
Chlorambucil & Cyclophosphamide
Thalidomide & Bortezomib

A

Chlorambucil & Cyclophosphamide

36
Q

The treatment of choice for patients with metastatic prostate cancer:

Tamoxifen
Elimination of testosterone production by the testes by surgical or chemical castration.
Carmustine
Lapatinib

A

Elimination of testosterone production by the testes by surgical or chemical castration.

37
Q

Bacitracin is not given parenterally because it is highly nephrotoxic. Bacitracin’s major use is for topical application.

The 1st and second statement are true.
Both statement are false
First statement is true & the second statement is false
First statement is false & the second statement is true.

A

The 1st and second statement are true.

38
Q

Cisplatin:

Chemical warfare
Platinum analog
Nitrogen mustard
First antineoplastic agent

A

Platinum analog

39
Q

A semisynthetic derivative of podophyllotoxin which is extracted from the mayapple root.

Doxorubicin
Mitomycin
Topotecan
Etoposide

A

Etoposide

40
Q

A folic acid analog which binds with high affinity to the active catalytic site of dihydrofolate reductase.

Methotrexate
Pemetrexed
TAS-102
5-fluorouracil

A

Methotrexate

Pharmacology II (8 decks)

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