endocrine pancreas, Diabetes Mellitus Flashcards
what cells make up the Islets of Langerhans?
α cells
β cells
δ cells
PP cells
what do α cells secrete?
glucagon
what do β cells secrete?
Insulin and Amylin
what do δ cells secrete?
Somatostatin
what do PP cells secrete?
Pancreatic Polypeptide
what is insulin?
polypeptide hormone with 2 amino acid chains
how are the 2 amino acid chains of insulin liked?
2 disulphide bonds
how is insulin secretion regulated?
Insulin secretion is tightly regulated and is controlled by blood levels of various nutrients, neural stimulation and hormones.
what is the principle stimulus to insulin secretion?
glucose
what are the endogenous factors controlling insulin secretion?
incretins
GIP: glucose-dependent insulinotropic peptide
GLP-1: glucagon-like peptide-1
where is insulin released into?
into the portal vein
what is the half life of insulin in plasma?
5-6 minutes
what is the half life of proinsulin in plasma?
17 minutes
what is the half life of C peptide in the plasma?
30 minutes
How does the degradation of insulin occur?
Proteolytic degradation of insulin occur mainly in liver, kidney & muscle usually after internalisation of insulin
what is the main hormone in controlling metabolism of carbohydrate, fat and protein?
insulin
what is the most obvious cause effect of insulin?
reduce the blood glucose and is the only hormone capable of reducing blood glucose level.
what are long term effects of insulin?
Increase & decrease of key enzymes &
Stimulates cell proliferation
what are the effects of insulin on the liver?
Increased glycogen synthesis (↑glycogenesis)
Increased use of glucose for the energy (↑glycolysis)
Increased fat synthesis (↑lipogenesis)
Decreased synthesis of ketone bodies (↓ketosis)
what metabolic process of the liver does insulin decrease?
ketosis - synthesis of ketone bodies
what are the actions of insulin on fatty tissues?
Increased glucose uptake
Increased fatty acid uptake
Increased fat synthesis
Increased glycolysis
what are the actions of insulin on muscle?
Increased glucose uptake
Increased uptake of amino acids
Increased glycogenesis
Increased glycolysis
what is glucagon?
Single chain peptide of 29 amino acids synthesized by α cells of pancreatic islets.
what is the main physiological stimuli of glucagon?
amino acids in plasma
Do high or low concentrations of fatty acids and glucose stimulate glucagon secretion?
low concentrations
Do high or low concentrations of fatty acids and glucose inhibit glucagon secretion?
high concentration
how does somatostatin impact glucagon release?
Somatostatin inhibits glucagon release
how do catecholamines and cholinergic impact glucagon release?
Catecholamines & cholinergic stimulation both increase glucagon release
what is the half life of glucagon?
3-6 minutes
where is the primary site of action for glucagon?
liver
where does glucagon increase glycogenolysis?
liver
where does glucagon increase gluconeogenesis?
liver and kidney
where does glucagon reduce glycogen synthesis?
liver
where does glucagon reduce glucose oxidation?
liver
where does glucagon increase lipolysis?
liver and fat
where does glucagon increase ketogenesis?
liver
where does glucagon reduce lipogenesis?
liver