Endocrine key conditions

Question 1

Name 2 ovarian causes of hirsutism:

Answer 1

PCOS (90%)
Virilising tumour

Question 2

Name 2 adrenal causes of hirsutism:

Answer 2

CAH
Cushings / adrenal carcinoma

Question 3

What is the triad of complaints relating to PCOS?

Answer 3

Hirsutism / acne
Oligo / amenhorrea
Subfertility

Question 4

Name 4 biochemical features of PCOS:

Answer 4

1. insulin resisitance
2. raised testosterone
3. raised LH / FSH ratio
4. raised prolactin

Question 5

Regarding MEN: which class features Marfanoid appearances?

Answer 5

IIb

Question 6

Regarding MEN: which class features phaeochromocytomas?

Answer 6

IIa + IIb

Question 7

Regarding MEN: which class features parathyroid hyperplasia?

Answer 7

IIb

Question 8

Regarding MEN: which class features parathyroid adenoma?

Answer 8

I

Question 9

Regarding MEN: which class affects chromosome 11?

Answer 9

I

Question 10

Regarding MEN: which class features Zollinger tumours?

Answer 10

MEN 1
Pancreas -> Zollinger (gastin secreting tumour)

Question 11

Which MEN class features Medullary thyroid cancers?
How is disease monitored?

Answer 11

IIa + IIb
measure calcitonin levels

Question 12

How does one treat phaeochromocytoma?

Answer 12

First: alpha blockade (Phenoxybenzamine)

Then: beta blockade (Propanolol)

Question 13

Which chromosome is MEN 2 associated with?

Answer 13

10