Endocrine + Hormones Flashcards
Endocrine system
Group of ‘ductless’ glands that secrete hormones into the bloodstream
Hormones
Chemicals responsible for long term regulation of many bodily functions
- They may:
- Activate certain genes in nucleus to produce a particular enzyme/protein
- They may:
- Change shape/structure of enzyme to turn it “on or off”
- They may:
- Change rate of production by changing rate of transcription/ translation
Hormones may affect:
- All body cells
- Target cells
- Target organs
Types of hormones
- Steroid
- Protein
- Amine
Steroid hormones
- Lipid soluble
2.Membrane receptor in nucleus/cytoplasm - Slow but long lasting
- Modifies gene activity (protein synthesis)
protein/ amine hormones
- Water soluble
- Membrane receptor ON cell membrane
- Quick but short lasting
- Causes C-AMP to be released
- can activate enxymes
Receptor proteins
They are specific to one molecule (lock and key analogy)
Saturation
When each receptor is bound to a molecule there is not further increase in cell activity rate.
Enzyme amplification
one hormone molceule activates thousands of molecules
Hormone clearance
Hormone molecules are turned off by breaking it down by either target cells or the liver and kidneys.
Negative feedback hormones
hormone secretion must be closely regulated to prevent abnormal bodily function