Endocrine drugs Flashcards
1
Q
what is the main drug used to treat hyperthyroidism? what is its MOA?
A
CARBIMAZOLE: inhibits thyroid peroxidase from coupling and iodinating tyrosine residues on thyroglobulin - reduces thyroid hormone production.
2
Q
main ADRs of carbimazole?
A
- Agranulocytosis - advise pt to seek medical advice if sore throat, mouth ulcers, bruising, fever, malaise…
- Crosses placental barrier - but may still be used at low dose in pregnancy if benefits > risks