Anti-emetics Flashcards
1
Q
describe the MOA of metoclopramide. What are its common indications?
A
MOA: prokinetic - D2 receptor antagonist (decreases motility in upper GIT and increases motility in lower GI tract)
- nausea and vomiting in migraine, delayed chemotherapy-induced or radiotherapy-induced
- prevention of post-op nausea and vomiting
- gastroparesis secondary to diabetic neuropathy
2
Q
suggest possible ADRs of metoclopramide
A
extrapyramidal effects
- oculogyric crisis
- tardive dyskinesia
- parkinsonism
- hyperpolactinaemia +/- galactorrhoea
- prolonged QT interval
- neuroleptic malignant syndrome
3
Q
name CIs for metoclopramide
A
- GI obstruction
- GI haemorrhage or perforation
- 3-4 days after GI surgery
- phaeochromocytoma
4
Q
what is the MOA of cyclizine? What are its common indications?
A
MOA: histamine H1 R antagonist, also possesses anticholingeric properties
- nausea and vomiting
- vertigo
- motion sickness
- labyrinthine disorders
5
Q
describe possible ADRs of cyclizine
A
- drowsiness, restlessness
- blurred vision
- dry mouth
- closed angle glaucoma
- extra-pyramidal symptoms inc. oculogyric crisis
- rash
