Endocrine Drugs Flashcards

1
Q

Name the 2 drugs used to treat hypothyroidism

A

1.LIOTHYRONINE(T3)… IV-emergency use,fast onset but short acting
2.LEVOTHYROXINE(T4)…oral prodrug,long acting

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2
Q

Name drugs used to treat hyperthyroidism

A

1.CARBIMAZOLE… prodrug,take long to act
2.PROPYLTHIOURACIL…works rapidly
* the 2 are thyroperoxidase inhibitors
3.PROPANOLOL… beta blocker since tachycardia is one of the symptoms

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3
Q

How do you treat hyperthyroidism for patients with neutropenia & agranulocytosis

A

Use BLOCK & REPLACE method,block insulin release totally and use LEVOTHYROXINE to replace it
*symptoms if the 2 conditions; sore throat
Rash
Headache
Joint pain

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4
Q

Name the 2 drugs used to treat Addison’s disease( adrenal deficiency)

A

1.HYDROCORTISONE( glucocorticoid)…. Synthetic cortisol
2.FLUDROCORTISONE(mineralocorticoid)….unnecessary for pituitary failure

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5
Q

Glucocorticoids drugs are used bcz of their anti-inflammatory & immunosuppressive effects,name these drugs;

A

1.HYDROCORTISONE…topical use
2.PREDNISOLONE…oral
3.BETAMETASONE
4.DEXAMETASONE
5.BECLOMETASONE…topical use

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6
Q

Name the 2 glucocorticoids drugs used to treat asthma

A

1.FLUTICASONE…inhaled in STEP 2
2.PREDNISOLONE…oral in STEP 5

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7
Q

If oral steroids such as PREDNISOLONE are abruptly withdrawn,what problems can this cause?

A

Hypotension
Fever
Weight loss
* hence if more than 3 weeks of use,DO NOT withdraw corticosteroids abruptly

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8
Q

What are the adverse effects of using MINERALOCORTICOIDS such as fludrocortisone?

A

Fluid retention
Hypertension
K/Ca loss

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9
Q

What are the adverse effects of using glucocorticoids

A

Diabetes
Osteoporosis
Muscle wasting
Peptic ulcer
Cushing’s syndrome

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10
Q

What is ADH used to treat

A

DIABETES INSIPIDUS

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11
Q

Name an adh type drug used to treat Syndrome of inappropriate ADH secretion(SIADS)

A

TOLVAPTAN
* a V2 receptor antagonist

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12
Q

Name ADH type drugs used to treat DIABETES INSIPIDUS

A

DESMOPRESSIN(V2)
CARBAMAZEPINE(anti epileptic)
THIAZIDE(diuretic)
Terlipressin…vasoconstriction(v1)

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13
Q

What oxytocin type drug is used to prevent premature labor

A

ATOSIBAN

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14
Q

Name the Prostaglandin E1 analogue drug,used for early therapeutic ABORTION

A

MISOPROSTOL

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15
Q

What is DINOPROSTONE(PGE2) drug used for

A

Induce labor
Induce late therapeutic abortion

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16
Q

What do oral contraceptives contain to inhibit ovulation

A

Combination of Oestrogen & Progestin