Diuretics And Incontinence Drugs Flashcards
What the mechanism of action of loop diuretics
Inhibit NKCC2 symporters(NA-K-Cl)
Name loop diuretics drugs
FUROSEMIDE
TORSEMIDE
BUMETANIDE- more selective
What’s the mode of action of osmotic diuretics
Inhibit water reabsorption, uses osmotic pressure/force
What 2 types of diuretics act on the PCT & loop of Henle
Loop diuretics
Osmotic diuretics
Which 2 types of diuretics act on the distal convulated tubule & collecting duct
Potassium sparing drugs
Thiazide drugs
What’s the 2 mechanism of action of Potassium Sparing drugs
Inhibition of epithelial Sodium Channels (ENaCs)
Inhibition of Aldosterone receptors
What’s the mode of action of thiazide diuretics
Inhibition of Na/K cotransporter s
Name the potassium sparing diuretic that act by inhibiting ENaCs
AMILORIDE
Name the K-sparing diuretic drug that inhibits aldosterone receptors
SPIRONOLACTONE
What are the side effects of K-sparing drugs
Decrease K excretion hence may lead to;
HYPERKALEMIA
METABOLIC ACIDOSIS- limit proton excretion esp Spironolactone
Name the thiazide diuretic drugs
BEDROFLUMETHAZIDE
INDAPAMIDE
Whats the mechanism & site of action of carbonic anhydrase inhibitors
Act on PCT, decreasing bicarbonate reabsorption
Why carbonate anhydrase inhibitors help treat GLAUCOMA
Ciliary body produce aqueous humor with help of carbonic anhydrase enzyme,hence its inhibition decrease the production & therefore decreasing the pressure
Name the carbonic anhydrase inhibitor diuretic drugs
(-zolamide)
METHAZOLAMIDE
ACETAZOLAMIDE
Name the 3 different classes of anti-incontinence drugs
1.Anticholinergic drugs
2.Alpha-1 adrenoreceptor antagonists
3.Beta-3 adrenoreceptor agonist
