Endocrine and General Medical Flashcards
Cause of Diabetic Ketoacidosis
Lack of Insulin or Insulin Resistance.
Excess blood sugar causes increased water in body which diuresis fluid, Potassium, and Phosphorus. (Causing Metabolic Acidosis)
Treatment of Diabetic Ketoacidosis
Aggressive fluid hydration K+ and Pho4 replacement Insulin dosing at 0.1 u/kg Consider D5w once CBG <300 mg/dl Do not drop glucose >100 mg/dl/hr
Hyperglycemic Hyperosmolar Non-ketonic Coma (HHNK/HHNC)
Excessive sugar but body is still making and using insulin
Presentation of HHNK
Severe dehydration Hyperglycemia (>800 common) Elevated BUN /Creatine Hypernatremia No Ketones
Treatment of HHNK
Aggressive fluid replacement
Insulin
Anticipate hypokalemia
Cause of Diabetes Insipidus (DI)
Lack of anti-diuretic hormone caused by Head injury or Dilantin
Presentation of Diabetes Insipidus
Extreme urinary output with low osmolarity and specific gravity.
Hypernatremia
Treatment of Diabetes Insipidus
Aggressive fluid replacement
Vasopressin
dDavP
Syndrome of Inappropriate Antidiuretic Hormone (SIADH)
Excessive production of ADH
Causes of SIADH
Small cell / oat cell carcinoma
Head injury
Presentation of SIADH
Dilutional Hyponatremia
Seizures
Cerebral edema
Elevated Urine osmolarity / specific gravity
Treatment of SIADH
Restrict fluids
Diuresis
Demeclocycline (ADH receptor antagonism)
GI Hemorrhage Treatment
Treat shock with 3:1 Crystalloid/Blood
NG/OG
Octreotide (Sandostatin) 25-50 mcg IVP then drip
Vasopressin
Causes of Grave’s Disease / Thyrotoxicosis (Thyroid storm / Hyperthyroid)
Increased Thyroid production due to surgery Uncontrolled DM
AMI
Toxemia
Presentation of Grave’s Disease (Hyperthyroid)
Any new tachycardia/A Fib in otherwise healthy females
Dramatic weight loss
CP /SOB/ Palpitations
Tremors / Nervousness
Treatment of Grave’s Disease (Hyperthyroid)
Anti-thyroid Meds
Anti-pyretics
Consider Iv glucocorticoids (Dexmethasone)
Fluids / Electrolytes
Thyroid controls _____.
Metabolic rate (Body Idle Speed)
Causes of Hypothyroid / Myxedema Coma
Autoimmune disorder most commonly triggered by infection.
Officially Myxedema Coma upon any change in LOC.
Presentation of Hypothyroid
Primarily women, almost exclusively over age 60.
>90% of cases in winter.
Fatigue, weight gain, deep voice, coarse hair
Treatment of Hypothyroid
Levothyroxine
Supportive care