Endocrine

Question 1

In type 2 diabetes, what is waist circumference associated with?

Answer 1

With increasing waist circumference there is increasing CV risk

Question 2

Diabetes definition

Answer 2

Disorder of carbohydrate metabolism characterised by hyperglycaemia due to relative insulin deficiency, resistance or both

Question 3

Define insulin resistance

Answer 3

= lower glucose disposal for a set insulin load compared to that in s healthy/normal individual

Question 4

Why are sulfonylureas not first line tx in overweight type 2
diabetics

Answer 4

They increase apetite therefore can –> to further weight gain (worsening condition) but in diabetics who are not overweight they are initial tx of choice

Question 5

mechanism of metformin

Answer 5

decreases glucose production by liver
sensitizes target tissue to insulin
(= a biguanide)

Question 6

example of a sulfonylurea

Answer 6

glibenclamide