Endocrine

Question 1

Glyburide

Answer 1

MOA: sulfonylurea antidiabetic agent, increase insulin secretion from pancreas
Uses: diabetes mellitus type 2

Question 2

Insulin rapid/short acting
Lispro
Glulisine
Regular

Answer 2

MOA: Binds to endogenous insulin receptor
Uses: DM type 1 or 2

Question 3

Insulin intermediate/long acting
NPH
Glargine
Detemir

Answer 3

MOA: Binds to endogenous insulin receptor
Uses: DM type 1 or 2

Question 4

Metformin

Answer 4

MOA: Biguanide antidiabetic, decreases hepatic glucose production & increases insulin sensitivity
Uses: DM type 2

Question 5

Norgestimate/ethinyl estradiol

Answer 5

MOA: Suppression of gonadotropins, inhibition og ovulation
Uses: oral contraceptive

Question 6

Rosiglitazone

Answer 6

MOA: Insulin sensitizers, improves insulin action in the presence of insulin
Uses: DM type 2

Question 7

Sitagliptin

Answer 7

MOA: DPP4 inhibitor
Uses: DM type 2

Question 8

Levothyroxine (T4)

Answer 8

MOA: T4 is converted to T3 by 5’DI, T3 then moves to nucleus & binds ligand-binding domain of the thyroid receptor (TR), this promotes disruption of the TR, displacement of the corepressers & binding of coactivstors, TR coactivator complex activates gene transcription leading to alteration in protein synthesis & cellular phenotype
Uses: Hypothyroidism