Endocrine-2 (Pharmacology)

Question 1

What enzyme that is involved in the conversion of androstenedione/testosterone into estrone/estradiol?

Answer 1

Aromastase (CYP19)

Question 2

Which of the following is an antiprogestin that inhibits ovulation?

Answer 2

Ulipristal acetate

Question 3

Which of these drugs is a pure estrogen receptor antagonist that inhibits pituitary estrogen receptors, thereby inhibiting estrogen feedback and stimulating LH release?

Answer 3

Clomiphene

Question 4

Which of these drugs has different effects (agonist/antagonist) at different estrogen receptor subtypes?

Answer 4

Tamoxifen

Question 5

During the follicular phase of the menstrual cycle, estrogen:

Answer 5

Inhibits LH/FSH

Question 6

What enzyme metabolizes testosterone to dihyrotestosterone?

Answer 6

5α-reductase

Question 7

What is the effect of esterification of testosterone analogues on ADME characteristics?

Answer 7

Reduced liver metabolism and extended half-life

Question 8

Which is an inactive metabolite of testosterone formed in the liver?

Answer 8

Adrosterone

Question 9

Complete Androgen Insensitivity resulting from androgen receptor gene mutations produces what effect(s)?

Answer 9

Morphological female development

Question 10

Which hormone stimulates the synthesis of testosterone?

Answer 10

LH