Endocrine Flashcards
What is Cushing disease
Hypercortism… too much cortisol
What does cortisol do?
Controls wakefulness and daily cycle
Suppresses immune system
Causes liver to release glucose…glycolysis
Breaks down muscle to change protein into glucose gluconeogenisis
Works on pancreas to decrease insulin and increase glucagon to increase blood sugar
Breaks down fat initially but with increased blood sugar Causes increased adipose tissue
What Causes Cushing disease?
What Causes Cushing disease?
It is caused by either a tumor or by the use of steroids to treat other diseases
Steroids are often used to turn down the immune system if someone is having an overreaction to an infection or autoimmune disease
For EG… asthma, ulcerative colitis, MS, rheumatoid arthritis
What are the signs and symptoms of Cushing disease?
Hyperglycemia and the dev of DM2 (glucose intolerance)
Polyuria (body urinating out excess sugar)
Enormous quick adipose tissue accumulations around the axial skeleton EG moon face, Buffalo hump, truncal obesity
Protein wasting leading to..weakness, thin arms and legs from muscle loss, kyptosis and osteoporosis from loss of protein in bone matrix, strike and bruising from the loss of collagen, hypertension (from stimulus of aldesterone), immunosuppressive, poor wound healing from hyperglycemia
What is the treatment of Cushing disease?
Surgery if increased cortisol or ACTH is from tumor
Titration off steroids slowly to prevent Addington crisis
Stuff about aldosterone
Renin is timulated when the BP is low amd thr glom doesn’t have enough BP to filter blood
This causes thr release of ALDOSTERONE
aldosterone travels to the distal convoluted tubule (same place as ADH)
While ADH pulls in water BUT NOT SODIUM, aldosterone pulls in SODIUM…it also excreted potassium
WATER ALWAYS FOLLOWS SODIUM…so aldosterone ends up increasing the BP by pulling in both sodium AND water
When BP increases and the glom has enough pressure to filter it stops secreting renin
