Endocrine

Question 1

Which drug causes both decreased bone resorption and increased bone formation

Answer 1

Strontium ranelate

Question 2

Receptors on beta cells of pancreas

Answer 2

GLUT 1
GLP 1

Question 3

Insulisn dependent uptake occurs via

Answer 3

GLUT 4

Question 4

2 drugs used in both type 1 and 2 DM

Answer 4

Insulin
Amylin analogues

Question 5

Pioglitazone and metformin do not cause

Answer 5

Hypoglycemia

Question 6

Side effects of alfa glucosidase inhibitor

Answer 6

Flatulence, osmotic diarrhea
C/I in renal failure

Question 7

GLP 1 analogues given via

Answer 7

Subcutaneous

Question 8

Liraglutide effect on weight

Answer 8

Loss
DOC for obesity
Causes delayed gastric emptying

Question 9

Side effects of DPP4 inhibitor

Answer 9

Pancreatitis
Weight neutral
Risk of infection(respiratory)
SJS
C/I renal failure except Linagliptin

Question 10

Pramlintide is a

Answer 10

Amylin analogue given subcutaneous
If Given with insulin reduce dose of insulin by 50% as there is high risk of hypoglycemia

Question 11

All insulin are colorless except

Answer 11

NPH(milky turbid)
also afrezza which is powder

Question 12

Lente insulin

Answer 12

30 %semi lente and 70% ultra lente

Question 13

Only insulin with acididc pH

Answer 13

Glargine
Forms crystals if added with another insulin in same syringe

Question 14

Pioglitazone is a

Answer 14

PPAR gamma stimulator

Question 15

Pioglitazone side effects

Answer 15

Weight gain due to Na water retention, can ppt CHF
Osteoporosis
Macular edema
Hepatotoxic

Question 16

MOA of metformin

Answer 16

Decrease hepatic glucose production by stimulating AMPK( block gluconeogenesis)
Also Decrease insulin resistance
Decrease gastric emptying

Question 17

Pegvisomant is

Answer 17

GH receptor antagonist used in Resistant acromegaly
S/E- pituitary adenoma
Target to keep GH below 2.5ng/ml in acromegaly

Question 18

IGF1 analogue

Answer 18

Mecasermin
Can cause hypoglycemia as side effect

Question 19

Effect of somatostatin on thyroid

Answer 19

Decrease release of TSH from pituitary so hypothyroidism