Endocrine Flashcards
Which drug causes both decreased bone resorption and increased bone formation
Strontium ranelate
Receptors on beta cells of pancreas
GLUT 1
GLP 1
Insulisn dependent uptake occurs via
GLUT 4
2 drugs used in both type 1 and 2 DM
Insulin
Amylin analogues
Pioglitazone and metformin do not cause
Hypoglycemia
Side effects of alfa glucosidase inhibitor
Flatulence, osmotic diarrhea
C/I in renal failure
GLP 1 analogues given via
Subcutaneous
Liraglutide effect on weight
Loss
DOC for obesity
Causes delayed gastric emptying
Side effects of DPP4 inhibitor
Pancreatitis
Weight neutral
Risk of infection(respiratory)
SJS
C/I renal failure except Linagliptin
Pramlintide is a
Amylin analogue given subcutaneous
If Given with insulin reduce dose of insulin by 50% as there is high risk of hypoglycemia
All insulin are colorless except
NPH(milky turbid)
also afrezza which is powder
Lente insulin
30 %semi lente and 70% ultra lente
Only insulin with acididc pH
Glargine
Forms crystals if added with another insulin in same syringe
Pioglitazone is a
PPAR gamma stimulator
Pioglitazone side effects
Weight gain due to Na water retention, can ppt CHF
Osteoporosis
Macular edema
Hepatotoxic
MOA of metformin
Decrease hepatic glucose production by stimulating AMPK( block gluconeogenesis)
Also Decrease insulin resistance
Decrease gastric emptying
Pegvisomant is
GH receptor antagonist used in Resistant acromegaly
S/E- pituitary adenoma
Target to keep GH below 2.5ng/ml in acromegaly
IGF1 analogue
Mecasermin
Can cause hypoglycemia as side effect
Effect of somatostatin on thyroid
Decrease release of TSH from pituitary so hypothyroidism
