Endo Flashcards
1
Q
Best DM med for ASCVD or CKD
A
GLP-1 receptor agonist or SGLT-2 inhibitor
2
Q
Metformin
A
Activates amp-kinase 1-2% A1C reduction Weight: neutral or reduction Side effects: GI, lactic acidosis Evidence of CVD reduction
3
Q
Sulfonylurea
A
Stimulates insulin secretion Glipizide, glimeperide 1-2% A1C reduction Weight gain Hypoglycemia No evidence of CVD reduction
4
Q
Thiazolidinedione
A
Activates nuclear transcription factor Pioglitazone, rosiglitazone 1-2% A1C reduction Weight gain Heart failure, edema CVD reduction
5
Q
DPP-4 inhibitor
A
Increases incretin secretion Sitagliptin, saxagliptin 0.5-1% A1C reduction Weight neutral Rare side effects No evidence of CVD reduction
6
Q
SGLT-2 inhibitor
A
Inhibits SGLT-2 in kidney Canaglifozin, empaglifozin 0.5-1% A1C reduction GU symptoms, UTI, dehydration Evidence of CVD reduction
7
Q
GLP-1 agonist
A
Mimics incretin Exenatide, liraglutide 1-2% A1C reduction Weight reduction GI, pancreatitis, medullary thyroid cancer Evidence of CVD reduction
