endo

Question 1

?

Answer 1

decreased libido

Question 2

kallman syndrome

Answer 2

defective hypothalmic gonadotropin realsing hormone and is associated with anosmia or hyposmia due to olfactory bulb agenesis or hypoplasia

prevents progression through puberty

Question 3

postpartum women with hyperprolactinemia and prominent pituitary mass

Answer 3

lymphocytic hypophysiitis

Question 4

empty sella

Answer 4

empty or partially empty sella
can hve normal pitutary function implying tht surrounding rim of pitutary tissue is functional
silent infarction csf filling

Question 5

pitutary apoplexy

Answer 5

spontaneously 
postpartum ( sheehan)
diabetes 
hypertension 
sicklecell anaemia 
shock 

tt
high dose glucocorticoids if no evident visual loss
if loss of vision consiousness cn palsy them surgical decompression

Question 6

?

Answer 6

normal or high growth hormone level

low insulin groeth levels

Question 7

sequence of hormone liloss in adult gh deficiency

Answer 7

GH 》FSH/LH》TSH》ACTH

Question 8

igf level provide useful index of therapeutic respinses but not sufficient for diagnosis

Answer 8

because its level can be normal in gh deficiency

Question 9

contraindications of gh replacement

Answer 9

active neolalsm
intracranial hypertension
uncontrolled diabetes
retinopathy

Question 10

?

Answer 10

male testosterone gnrh therapy for infertilty

females estrogen progestron

Question 11

features of sellar mass

Answer 11

table 4031Impacted StructureClinical ImpactPituitaryHypogonadismHypothyroidismGrowth failure and adult hyposomatotropismHypoadrenalismOptic chiasmLoss of red perceptionBitemporal hemianopiaSuperior or bitemporal field defectScotomaBlindnessHypothalamusTemperature dysregulationAppetite and thirst disordersObesityDiabetes insipidusSleep disordersBehavioral dysfunctionAutonomic dysfunctionCavernous sinusOphthalmoplegia with or without ptosis or diplopiaFacial numbnessFrontal lobePersonality disorderAnosmiaBrainHeadacheHydrocephalusPsychosisDementiaLaughing seizures

Question 12

stalk section phenomenon

Answer 12

pituitary stalk compression
disrupting pitituary of hypothalmic hormone and dopamine
decreasing all hormones except prolactin

Question 13

physiologic pituary enlargement in?

Answer 13

adoloscent and pregnancy

Question 14

prolactin suppresion by dopamine agonist doesnot neccesarily indicate tht underlying lesion is prolactinoma why?

Answer 14

because hyperprolactinemia caused by mass effect of nonlactotrope lesion is also corrected by treatment with dopamine agonist

Question 15

mainstay of tratment with micro macro prolactinemia

Answer 15

oral dopamine agonist

Question 16

dopamine agonist used pitutary prolactinoma

Answer 16

cabergoline

bromocriptine

Question 17

men tend to present with larger tumors why

Answer 17

because features of male gonadotropin deficiency r les likely evident

Question 18

causes of acromegaly

Answer 18

•Excess Growth Hormone Secretion
Pituitary Densely or sparsely granulated GH cell adenoma Mixed GH cell and PRL cell adenoma
Mammosomatotrope cell adenoma
Plurihormonal adenoma
GH cell carcinoma or metastases
Multiple endocrine neoplasia 1 (GH cell adenoma)
McCune-Albright syndrome
Ectopic sphenoid or parapharyngeal sinus pituitary adenoma •Extrapituitary tumor
Pancreatic islet cell tumor
Lymphoma Although these tumors usually express positive GHRH immunoreactivity, clinical features of acromegaly are evident in only a minority of patients with carcinoid disease.
Excessive GHRH
also may be elaborated by hypothalamic tumors, usually choristomas or neuromas. Presentation and Diagnosis Protean manifestations of GH and IGF-I hypersecretion are indolent and often are not clinically diagnosed for 10 years or more. Acral bony overgrowth results in frontal bossing, increased hand and foot size, mandibular enlargement with prognathism, and widened space between the lower incisor teeth. In children and adolescents, initiation of GH hypersecretion before epiphyseal long bone closure is associated with development of pituitary gigantism (Fig. 403-4). Soft tissue swelling results in increased heel pad thickness, increased shoe or glove size, ring tightening, characteristic coarse facial features, and a large fleshy nose. Other commonly encountered clinical features include hyperhidrosis, a deep and hollow-sounding voice, oily skin, arthropathy, kyphosis, carpal tunnel syndrome, proximal muscle weakness and fatigue, acanthosis nigricans, and skin tags. Generalized visceromegaly occurs, including cardiomegaly, macroglossia, and thyroid gland enlargement. The most significant clinical impact of GH excess occurs with respect to the cardiovascular system. Coronary heart disease, cardiomyopathy with arrhythmias, left ventricular hypertrophy, decreased diastolic function, and hypertension ultimately occur in most patients if untreated. Upper airway obstruction with sleep apnea occurs in more than 60% of patients and is associated with both soft tissue laryngeal airway obstruction and central sleep dysfunction. Diabetes mellitus develops in 25% of patients with acromegaly, and most patients are intolerant of a glucose load (as GH counteracts the action of insulin). Acromegaly is associated with an increased risk of colon polyps and mortality from colonic malignancy; polyps are diagnosed in up to one-third of patients. Overall mortality is increased about threefold and is due primarily to cardiovascular and cerebrovascular disorders and respiratory disease. Unless GH levels are controlled, survival is reduced by an average of 10 years compared with an age-matched control population. Laboratory Investigation Age-matched serum IGF-I levels are elevated in acromegaly. Consequently, an IGF-I level provides a useful laboratory screening measure when clinical features raise the possibility of acromegaly. Due to the pulsatility of GH secretion, measurement of a single random GH level is not useful for the diagnosis or exclusion of acromegaly and does not correlate with disease severity. The diagnosis of acromegaly is confirmed by demonstrating the failure of GH suppression to <0.4 μg/L within
Excess Growth Hormone–Releasing Hormone Secretion Central Hypothalamic hamartoma, choristoma, ganglioneuroma
Peripheral Bronchial carcinoid, pancreatic islet cell tumor, small cell lung cancer, adrenal adenoma, medullary thyroid carcinoma, pheochromocytoma

Question 19

features of acromegaly

Answer 19

•Acral bony overgrowth results in frontal bossing, increased hand and foot size, mandibular enlargement with prognathism, and widened space between the lower incisor teeth. In children and adolescents, initiation of GH hypersecretion before epiphyseal long bone closure is associated with development of pituitary gigantism
•Soft tissue swelling results in
increased heel pad thickness,
increased shoe or glove size,
ring tightening,
characteristic coarse facial features, and a large .

generalized visceromegaly occurs, including cardiomegaly, macroglossia, and thyroid gland enlargemen

Other commonly encountered clinical features include hyperhidrosis, a deep and hollow-sounding voice, oily skin,  arthropathy,  kyphosis,  carpal  tunnel  syndrome,  proximal  muscle weakness and fatigue, acanthosis nigricans, and skin tags. Get.

Question 20

additional treatment of growth hormone secreating adenoma

Answer 20

surgical correction

Question 21

medical treatment of growth hormone secreating adenoma

Answer 21

somatostatin analges octrotide lanreotide
therapeutic effects somatostatin receptors whuch r presnt of gh secreating tumors
Adverse effects are
git mainly

short-lived and mostly relate to druginduced suppression of gastrointestinal motility and secretion. Transient nausea, abdominal discomfort, fat malabsorption, diarrhea, and flatulence
. Octreotide suppresses postprandial gallbladder contractility and delays gallbladder emptying; develop long-term echogenic sludge or asymptomatic cholesterol gallstones. Other side effects include mild glucose intolerance due to transient insulin suppression, asymptomatic bradycardia, hypothyroxinemia, and local injection site discom

•gh receptor antagonst
pegvisomant

• dopamine agonist
suppress growth hormone secretion cabergoline

Question 22

clinical features of cushing syndrome

Answer 22

Obesity or weight gain (>115% ideal body weight) 
Thin skin Moon facies
 Hypertension
 Purple skin striae 
Hirsutism 
Menstrual disorders (usually amenorrhea)
 Plethora A
bnormal glucose tolerance 
Impotence P
roximal muscle weakness
 Truncal obesity
 Acne B
bruising 
Mental changes
 Osteoporosis 
 Edema of lower extremities
 Hyperpigmentation 
Hypokalemic alkalosis
 Diabetes mellitus

Question 23

use of petrosal sinus venous sampling

Answer 23

differntiate between pitutary adenoma and acth secreating tumors

Question 24

treatment of choice cushing ds

Answer 24

selective transpenoidal resection

Question 25

drugs used in cushing syndrome

Answer 25

``` somatostatin analogue pasirotide hyoerglycemia diabetes due to suppressed secretion of pancreatic secretion of insulin and increatins glucocorticoids receptors antagonists mifepristone steroidogenic inhibitors ketoconazole inhibit cytp450 metrapone inhibits 11b hydroxylase ```

Question 26

nelson syndrome

Answer 26

Adrenalectomy in the setting of residual corticotrope adenoma tissue predisposes to the development of Nelson’s syndrome, a disorder characterized by rapid pituitary tumor enlargement and increased pigmentation secondary to high ACTH levels. Prophylactic radiation therapy may be indicated to prevent the development of Nelson’s syndrome after adrenalectomy.

Question 27

most common type of pituitary adenoma

Answer 27

non functional

Question 28

MOA of AVP

Answer 28

Antidiuresis is mediated via binding to G proteincoupled V2 receptors on the serosal surface of the cell, activation of adenyl cyclase, and insertion into the luminal surface of water channels composed of a protein known as aquaporin 2 constriction of smmoth muscles in blood vessels and git

Question 29

drug essential in sheehan syndrome

Answer 29

glucocorticoids

Question 30

All are associated with pituitary apoplexy except- 1) Hyperthyroidism 2) Diabetes mellitus 3) Sickle cell anemia 4) Hypertension

Answer 30

hyperthyroidism

Question 31

most common cause of GHRH mediated acromegaly

Answer 31

chest or abdominal carcinoid

Question 32

Nelson's syndrome is most likely seen after - 1) Hypophysectomy 2) Adrenalectomy 3) Thyroidectomy 4) Orchidectomy

Answer 32

adrenalectomy

Question 33

Tolvaptan is approved for use in- 1) High Na 2) High K 3) High Ca 4) Low Na

Answer 33

low na

Question 34

Treatment of lithium induced diabetes insipidus - 1) Vasopressin 2) Mineralocorticoid antagonist 3) Amiloride 4) Loop diuretic

Answer 34

amiloride

Question 35

causes of diabetes insipidus

Answer 35

pituitary di gestational DI secondary DI due to ongibition of avp by excess fliud intake also known as primary polydypsia 3 subcategories dipsogenic di psychogenic di ioatrogenic di nephrogenic di

Question 36

most common cause of preventable mental retardation

Answer 36

iodine deficiency

Question 37

most common cause of preventable mental retardation

Answer 37

iodine deficiency

Question 38

cause of cretinism

Answer 38

congenital hypothroidism thyroid hormone synthesis begin at 11 wks of gestation if there is no thyroid gland / hormone mother thyroid will compensate till birth so chance sof cretinism will be more in first few yrs of life if mother is also hypothyroid during pregnancy child will be born with cretinism

Question 39

TSH is realsed in pulsatile manner but single measurement is effective why

Answer 39

long half life of TSH

Question 40

wolff chaikoff effect

Answer 40

excess iodine transiently inhibits thyroid iodide organification

Question 41

CAUSE OF INCREASE and DECREASE IN TBG

Answer 41

``` increase in pregnancy ocp inflammatory liver ds tamoxifen serm ``` decrease in androgens nephorotic syn

Question 42

seum TBG levels are increased in all type of thyrotoxcossis except

Answer 42

thyrotoxic factitia caused by self admininstration of thyroid hormone

Question 43

function of tpo

Answer 43

oxidation of iodine | coupling of monoidottrosines and diiodotyrosines

Question 44

antibodies found in hypothyroidism

Answer 44

antiTPO antithyroglobulin anti TSH they r useful markers of autoimmunity

Question 45

cause of myxedema in hypothyroidism

Answer 45

increased dermal glycosaminoglycan content traps water giving rise to skin thickening without pitting

Question 46

symptoms of hypothyroidism

Answer 46

``` Symptoms Tiredness, weakness Dry skin Feeling cold Hair loss Difficulty conc entrating and poor memory Constipation Weight gain with poor appetite Dyspne a Hoarse voice Menorrhagia (later oligomenorrhea or amenorrhea) Paresthesia Impaired hearing ```

Question 47

signs of hypothyroidism

Answer 47

``` Signs Dry coarse skin; cool peripheral extremities Puffy face, hands, and feet (myxedema) Diffuse alopecia Bradycardia Peripheral edem a Delayed tendon reflex relaxation Carpal tunnel syndrome Serous cavity effusions ```

Question 48

effect of hypothyroidism on cvs

Answer 48

decrease in stroke volume | increase in periferal vascular resistence hypertension particularly diasystolic

Question 49

causes of hypothyroidism

Answer 49

PRIMARY Autoimmune hypothyroidism: Hashimoto’s thyroiditis, atrophic thyroiditis Iatrogenic: 131I treatment, subtotal or total thyroidectomy, external irradiation of neck for lymphoma or cancer Drugs: iodine excess (including iodine-containing contrast media and amiodarone), lithium, antithyroid drugs, p-aminosalicylic acid, interferon α and other cytokines, aminoglutethimide, tyrosine kinase inhibitors (e.g., sunitinib) Congenital hypothyroidism: absent or ectopic thyroid gland, dyshormonogenesis, TSH-R mutation Iodine deficiency Infiltrative disorders: amyloidosis, sarcoidosis, hemochromatosis, scleroderma, cystinosis, Riedel’s thyroiditis Overexpression of type 3 deiodinase in infantile hemangioma and other tumors TRANSIENT Silent thyroiditis, including postpartum thyroiditis Subacute thyroiditis Withdrawal of supraphysiologic thyroxine treatment in individuals with an Secondary intact thyroid After 131I treatment or subtotal thyroidectomy for Graves’ disease SECONDARY Hypopituitarism: tumors, pituitary surgery or irradiation, infiltrative disorders, Sheehan’s syndrome, trauma, genetic forms of combined pituitary hormone deficiencies Isolated TSH deficiency or inactivity Bexarotene treatment Hypothalamic disease: tumors, trauma, infiltrative disorders, idiopathic

Question 50

myxedema coma the

Answer 50

long standing hypothyroidism pt with no medication bradycardia, hypotension , stupor , coma delayed deep tendon reflex, seizures,other features of hypothyroidism precipitating factors severe illness , exposure to cold , eldrly factors tht impair respiration drugs pneumonia CHF,MI,GI bleed ,CVA

Question 51

TREATMENT of myxedema coma

Answer 51

iv bolos levothyroxine levothyronine t4 to t3 conversion is impaired hydrocortisone due to impaired adrenal reserve treat precipitating factors

Question 52

why t3 is not used in long term thyroid replacement

Answer 52

due to short half life 3-4 daiky doses hve to be given

Question 53

causes of thyrotoxcossis

Answer 53

CAuSES of THyRoToxiCoSiS Primary Hyperthyroidism Graves’ disease Toxic multinodular goiter Toxic adenoma Functioning thyroid carcinoma metastases Activating mutation of the TSH receptor Activating mutation of GSα (McCune-Albright syndrome) Struma ovarii Drugs: iodine excess (Jod-Basedow phenomenon) Thyrotoxicosis Without Hyperthyroidism Subacute thyroiditis Silent thyroiditis Other causes of thyroid destruction: amiodarone, radiation, infarction of adenoma Ingestion of excess thyroid hormone (thyrotoxicosis factitia) or thyroid tissue Secondary Hyperthyroidism TSH-secreting pituitary adenoma Thyroid hormone resistance syndrome: occasional patients may have features of thyrotoxicosis Chorionic gonadotropin-secreting tumorsa Gestational thyrotoxicosisa aCirculating TSH levels are low in these forms of secondary hyperthyroidism.

Question 54

difference bw thyotoxicosis and hyperthyroidism

Answer 54

?

Question 55

antibodies in graves ds

Answer 55

TSI

Question 56

can TSI cross placenta

Answer 56

yes so can cause thyrotoxcossis in fetus | antithyroid drugs given to mother will protect the fetus also as they will also cross placenta

Question 57

triad of graves ds

Answer 57

``` graves opthalmopathy eye signs grittiness tearing proptosis corneal damage periorbital edema scleral injection chemosis optic nerve compression dermopathy most frequently over ant and lateral aspect over lower leg pretibial myxedema non inflamed indurated plaque acropathy form of clubbing ```

Question 58

antithyroid druds

Answer 58

propylthiouracil carbimazole All inhibit the function of TPO, reducing oxidation and organification of iodide. These drugs also reduce thyroid antibody levels by mechanisms that remain unclear, and they appear to enhance rates of remission. Propylthiouracil inhibits deiodination of T4 →

Question 59

which antithyroid prevents t4>t3 conversion

Answer 59

propylthiouracil

Question 60

why propylthiouracil should not be given to children and pregnancy

Answer 60

hepatotoxic

Question 61

prevention of radioiodine induced throtoxic crisis

Answer 61

preadministtration of amtithyroid drugs decrease the hormone level but these drugs should be discontinued before radionucleotide treatment because it will prevent its uptake

Question 62

treatment of thyrotoxic crisis or thyroid strom

Answer 62

signs and symptoms fever delirium seizures , vomiting diarrohea jaundice hyperthermia arrythymia cardiac failure precipiting factors acute illness (e.g., stroke, infection, trauma, diabetic ketoacidosis), surgery (especially on the thyroid), or radioiodine treatment of a patient with partially treated or untreated hyperthyroidism drugs propylthiouracil doc will inhibit t4>t3 conversion methimazole iodine blocks thyroid hormone synthesis by wolf chaikoff effect propanolol esmolol adrenergic manifestations also prevent t4>t3conversion

Question 63

signs and symptoms of thyrotoxcossis

Answer 63

``` nS AnD SymPTomS of THyRoToxiCoSiS (DESCEnDing oRDER of fREquEnCy) SYMPTOMS Hyperactivity, irritability, dysphoria Heat intolerance and sweating alopecia Palpitations Fatigue and weakness Weight loss with increased appetite Diarrhea Polyuria Oligomenorrhea, loss of libido SIGNS Tachycardia; atrial fibrillation in the elderly Tremor Goiter Warm, moist skin Muscle weakness, proximal myopathy Lid retraction or lag Gynecomastia ```

Question 64

effect of thyrotoxcossis on cvs

Answer 64

``` sinus tachycardia palpitations increased stoke volume high output cardiac failure widened pulse pressure atrial fibrillation ```

Question 65

causes of throiditits

Answer 65

Acute Bacterial infection: especially Staphylococcus, Streptococcus, and Enterobacter Fungal infection: Aspergillus, Candida, Coccidioides, Histoplasma, and Pneumocystis Radiation thyroiditis after 131I treatment Amiodarone (may also be subacute or chronic) Subacute Viral (or granulomatous) thyroiditis Silent thyroiditis (including postpartum thyroiditis) Mycobacterial infection Drug induced (interferon, amiodarone) Chronic Autoimmunity: focal thyroiditis, Hashimoto’s thyroiditis, atrophic thyroiditis Riedel’s thyroiditis Parasitic thyroiditis: echinococcosis, strongyloidiasis, cysticercosis Traumatic: after palpation

Question 66

jod basedow effect and wolf chaikoff effect

Answer 66

jod basedow thyroid hormone synthesis is increased due to increased iodine

Question 67

factors altering thyroid function in pregnacy

Answer 67

Five factors alter thyroid function in pregnancy: (1) the transient increase in hCG during the first trimester, which stimulates the TSHR; (2) the estrogen-induced rise in TBG during the first trimester, which is sustained during pregnancy ; (3) alterations in the immune system, leading to the onset, exacerbation, or amelioration of an underlying autoimmune thyroid disease (see above); (4) increased thyroid hormone metabolism by the placenta; and (5) increased urinary iodide excretion, which can cause impaired thyroid hormone production in areas of marginal iodine sufficiency

Question 68

effect of amidorone on thyroid gland

Answer 68

both hypo/hyper initally hypo due to wolff chaikoff effect inhibits deiondinase and thyroid hormone receptors inc t3 dect4 inc tsh sometiime jod basedow effect occurs thyroid hormone synthesis becomes excessive as a result of inc iodine amt dure to underlying thyroid abnormality like graves or mng

Question 69

subacute throiditits also known as

Answer 69

This is also termed de Quervain’s thyroiditis, granulomatous thyroiditis, viral thyroiditis cause virus 3 phasss 1) thyrotoxic phase, , T4 and T3 levels are increased, reflecting their discharge from the damaged thyroid cells, and TSH is suppressed (2) hypothyroid phase, and-10). During this destructive phase, radioactive iodine uptake is low or undetectable. After several weeks, the thyroid is depleted of stored thyroid hormone and a phase of hypothyroidism typically occurs, with low unbound T4 (and sometimes T3) and moderately increased TSH levels (3) recovery phase.

Question 70

features of subacute

Answer 70

history of upper respiratory tract infection sore throat tender goiter

Question 71

tt of subacute

Answer 71

``` aspirin glucocorticoids beta blockers levothyroxine no role of antithyroid drugs ```

Question 72

painless thyroidits silent thyrodiits post partum thyroidits diffrernce from subacute are

Answer 72

painless normal esr pressence of tpo

Question 73

reidel thyrodiits

Answer 73

insidous onset painless dense fibrosis extend outside thyroid caosule local compression symptoms esophageal and neck veins hard nom tender asymmetric fixed difficulty to differenciate feom malignancy

Question 74

ses

Answer 74

``` due to severe diseases due to realses of cytokines most common hormone pattern low t3 total and unbound normal t4 normal tsh cause due to impair peripheral conversion of t4>t3 leading to inc reversed t3 amd normal t4 and tsh ``` decreasing catabolism in sarved or ill very sick pts dec in total t4 and t3

Question 75

types of goiter

Answer 75

diffuse nontoxic difuse enlargement absent of nodules non toxic multonodiukar goiter toxic multonodiula goitet

Question 76

environmental goitrogens

Answer 76

Endemic goiter is also caused by exposure to environmental goitrogens such as cassava root, which contains a thiocyanate; vegetables of the Cruciferae family (known as cruciferous vegetables) (e.g., Brussels sprouts, cabbage, and cauliflower); and milk from regions where goitrogens are present in grass.

Question 77

histologic changes

Answer 77

cytic areas with blood | lymphocytic invasuon ?

Question 78

risk facotrs of thyroid ca

Answer 78

k fACToRS foR THyRoiD CARCinomA in PATiEnTS wiTH THyRoiD noDulE History of head and neck irradiation, including total-body irradiation for bone marrow transplant and brain radiation for childhood leukemiaExposure to ionizing radiation from fallout in childhood or adolescenceAge <20 or >65 yearsIncreased nodule size (>4 cm)New or enlarging neck massMale genderFamily history of thyroid cancer, MEN 2, or other genetic syndromes associ-ated with thyroid malignancy (e.g., Cowden’s syndrome, familial polypo-sis, Carney complex)Vocal cord paralysis, hoarse voiceNodule fixed to adjacent structuresExtrathyroidal extensionLateral cervical lymphaden

Question 79

control of

Answer 79

hpa control gluco and adrenal androgen | raas mineralocorticoid

Question 80

low dose dexamethasone suppreses

Answer 80

normal person

Question 81

high dose dexamethasone suppresses

Answer 81

pitutary | acth secreting tumor not ectopic

Question 82

glucocorticoids act at

Answer 82

nuclear glucocorticoids receptors

Question 83

cause of antiimfammotory action of glucocorticoids

Answer 83

transrepression of proinflammatory genes

Question 84

cortisol is inactivated to corticosterone by

Answer 84

enzyme found predominantly in kidney signifiacance Cortisol and aldosterone bind the mineralocorticoid receptor (MR) with equal affinity; however, cortisol circulates in the bloodstream at about a thousandfold higher concentration. Thus, only rapid inactivation of cortisol to cortisone by 11β-HSD2 prevents MR activation by excess cortisol, thereby acting as a tissue-specific modulator of the MR pathway. In addition to cortisol and aldosterone, deoxycorticosterone (DOC) (F

Question 85

cushing ds

Answer 85

pitutary corticotrope adenoma

Question 86

most common cause of cushing syn

Answer 86

exogenous corticosteroids

Question 87

causes of cushing

Answer 87

Causes of Cushing’s Syndrome ACTH-Dependent Cushing’s Cushing’s disease (= ACTH-producing pituitary adenoma) Ectopic ACTH syndrome (due to ACTH secretion by bronchial or pancreatic carcinoid tumors, small-cell lung cancer, medullary thyroid carcinoma, pheochromocytoma and others) ACTH-Independent Cushing’s Adrenocortical adenoma Adrenocortical carcinoma

Question 88

signs and symptoms of cushing ds

Answer 88

SignS AnD SymPTomS of CuSHing’S SynDRomE Body Compartment/ System •Body fat Weight gain, central obesity, rounded face, fat pad on back of neck (“buffalo hump”) •Skin Facial plethora, thin and brittle skin, easy bruising, broad and purple stretch marks, acne, hirsutism •Bone Osteopenia, osteoporosis (vertebral fractures), decreased linear growth in children •Muscle Weakness, proximal myopathy (prominent atrophy of gluteal and upper leg muscles with difficulty climbing stairs or getting up from a chair •Cardiovascular system Hypertension, hypokalemia, edema, atherosclerosis •Metabolism ) Glucose intolerance/diabetes, dyslipidemia •Reproductive system Decreased libido, in women amenorrhea (due to cortisol-mediated inhibition of gonadotropin release) •Central nervous system Irritability, emotional lability, depression, sometimes cognitive defects; in severe cases, paranoid psychosis • Blood and immune system increased susceptibility to infections, increased white blood cell count, eosinopenia, hypercoagulation with increased risk of deep vein thrombosis and pulmonary embolism

Question 89

effect of glucocorticoids on carbo fats and proteins

Answer 89

gluconeogenesis lipolysis proteolysis catabolism

Question 90

why excess cortisol causes hypertension

Answer 90

because will not inactivated by kidney | more minerlacorticoid effect

Question 91

hyperpigmentation seen in which cusing ds

Answer 91

ectopic acth | occurs over knuckles scar mark skin area exposed to friction

Question 92

effect of ocp on cortisol level

Answer 92

increase cortisol binding protein so inc in total cortisone can give false positive result in cushing syndrome screening failure of dexamethasone suppression but 24 hr urinary free cortisol tells only abt free so no effect on this test

Question 93

how does concurrent intake of antiepileptics and rifampicin | effect screening

Answer 93

inactivate dexamethasone

Question 94

conns syndrome

Answer 94

aldosterone producing adrenal adenoma

Question 95

causes of mineralocoricoid excess

Answer 95

SES of minERAloCoRTiCoiD ExCESS Causes of Mineralocorticoid Excess Primary Aldosteronism Adrenal (Conn’s) adenoma Autonomous aldosterone excess . Bilateral (micronodular) adrenal hyperplasia Autonomous aldosterone excess Glucocorticoid-remediable hyperaldosteronism (dexamethasone-suppressible hyperaldosteronism)Crossover between the CYP11B1 and CYP11B2 genes results in ACTH-driven aldosterone production Other Causes Syndrome of apparent mineralocorticoid excess (SAME)Mutations in HSD11B2 result in lack of renal inactivation of cortisol to cortisone, leading to excess activation of the MR by cortisol Cushing’s syndrome Cortisol excess overcomes the capacity of HSD11B2 to inactivate cortisol to cortisone, con-sequently flooding the MR Glucocorticoid resistance Upregulation of cortisol production due to GR mutations results in flooding of the MR by cortisol Adrenocortical carcinoma Autonomous aldosterone and/or DOC excess Congenital adrenal hyperplasia Accumulation of DOC due to mutations in CYP11B1 or CYP17A1 Progesterone-induced hypertensionProgesterone acts as an abnormal ligand due to mutations in the MR gene Liddle’s syndrome Mutant ENaC β or γ subunits resulting in reduced degradation of ENaC keeping the mem-brane channel in open conformation f

Question 96

liddles syn

Answer 96

Liddle’s syndrome Mutant ENaC β or γ subunits resulting in reduced degradation of ENaC keeping the mem-brane channel in open conformation for longer enhacing mineralocorticoid excess

Question 97

clinaical manifestations of excess mineralocorticoid

Answer 97

``` hypokalemic hypertension hallmark na level normal potassium depletion metabolic alkalosis muscle weakness myopathy due to hypokalemia and alkalosis. periferal edema ```

Question 98

adrenal insufficiency

Answer 98

primary cause is adrenal secondary pitutary or hypothalmus if adrenal all 3 mineralo, gluco, androgen if secondary acth effected so no effect on mineralocorticoid because it is controlled by raas effect on glucocorticoids and androgens

Question 99

difference between primary and secondary adrenal insufficiency

Answer 99

PRIMARY Hyperpigmentation due to excess of proopiomelanicortin SECONDARY albaster colored pale skin due diffeciency of proopiomineralocortin

Question 100

cause of hyponatremia in primary and secondary adrenal insufficiency

Answer 100

primary dec mineralocorticoid | sec due to cortisol deficiency inc adh leading to siadh

Question 101

signs and symptoms of adrenal insufficiency

Answer 101

•Signs and Symptoms Caused by Glucocorticoid Deficiency TB>Fatigue, lack of energy Weight loss, anorexia Myalgia, joint pain Fever Normochromic anemia, lymphocytosis, eosinophilia Slightly increased TSH (due to loss of feedback inhibition of TSH release) Hypoglycemia (more frequent in children) Low blood pressure, postural hypotension Hyponatremia (due to loss of feedback inhibition of AVP release) ``` •Signs and Symptoms Caused by Mineralocorticoid Deficiency (Primary Adrenal Insufficiency Only) Abdominal pain, nausea, vomiting Dizziness, postural hypotension Salt craving Low blood pressure, postural hypotension Increased serum creatinine (due to volume depletion )Hyponatremia Hyperkalemia ``` •Signs and Symptoms Caused by Adrenal Androgen Deficiency Lack of energy Dry and itchy skin (in women) Loss of libido (in women) Loss of axillary and pubic hair (in women) •Other Signs and Symptoms Hyperpigmentation (primary adrenal insufficiency only) (due to excess of proopiomelanocortin [POMC]-derived peptides) Alabaster-colored pale skin (secondary adrenal insufficiency only) (due to deficiency of POMC-derived peptides)

Question 102

rule of 10

Answer 102

10% bilateral 10%exrtraadrenal 10% malignant

Question 103

difference between pheochromocttoma and paraganglioma

Answer 103

who restrict pheochromocttoma to adrenal tumor | and paraganglioma for tumors if al other sites

Question 104

clinical features of pheochromocytoma

Answer 104

CliniCAl fEATuRES ASSoCiATED wiTH PHEoCHRomoCyTomA, liSTED by fR£EquEnCy of oCCuRREnCE 1. Headaches 2. Profuse sweating 3. Palpitations and tachycardia 4. Hypertension, sustained or paroxysmal 5. Anxiety and panic attacks 6. Pallor 7. Nausea 8. Abdominal pain 9. Weakness 10. Weight loss 11. Paradoxical response to antihypertensive drugs 12. Polyuria and polydipsia 13. Constipation 14. Orthostatic hypotension 15. Dilated cardiomyopathy 16. Erythrocytosis 17. Elevated blood sugar 18. Hypercalcemia

Question 105

classic triad of pheochromocytoma

Answer 105

palpitations headache profuse sweating

Question 106

biochemical and imaging test for diagnosis of pheochromocytoma

Answer 106

``` CHEmiCAl AnD imAging mETHoDS uSED foR DiAgnoSiS of PHEoCHRomoCyTomA AnD PARAgAngliomA Diagnostic Method 24-h urinary tests Catecholamines Fractionated metanephrines Total metanephrines Plasma tests Catecholamines Free metanephrines Imaging CT M MRI MIBG scintigraphy Somatostatin receptor scintigraphya Fluoro-DOPA PET/CT ```

Question 107

false positive and false negative result of pheochromocytoma

Answer 107

exclude dietary or drug-related factors (withdrawal of levodopa or use of sympathomimetics, diuretics, tricyclic antidepressants, alpha and beta blockers) that might cause false-positive results and then to repeat testing or perform a clonidine suppression test (i.e.,

Question 108

causes of karyotypic abnormalities in turner and klinefelter

Answer 108

turner paternal nondysjunction structural abnormality mosaicism. klinefelter nondysjunction mosaicism

Question 109

features of klinefelter

Answer 109

``` •late puberty •gynaecomastia tall long legs facial body and pubic hair diminshed small penis testicular atrophy lower IQ • cardiovascular mitral valve prolapse • type 2 diabetes metabolic syndrome autoimmune ds breast cancer osteoporosis ```

Question 110

pathophysiology of klinefelter

Answer 110

•loss of sertoli leads to increase in fsh (as inhibin is decreased which inhibits fsh) increase the synthesis of aromatase in leydig cells leading to increse in conversion of androgen to estradiol •x chromosome with shorter cag repeats is inactivated leaving x chromosome with longer cag repeats on whic testosterone cannot act which along with inc conersion to estrogen causes feminization

Question 111

clinical manifestations of turner

Answer 111

``` short stature cubitus valgus knuckles knuckles dimple knuckle sign short 4th metatarsal or 4th metacarpal. shield chest widely spaced nipples pubic hair normal webbed neck in adult lymphedema of hands limbs neck in infancy cvs - left sided.heart ds streak gonads primary amenorrhea horse shoe kidney ```