Endo 2 Treatments and Diagnosis Flashcards
Lab findings of hypoglycemia, ↑ LFTs, or CPK
(creatine phosphokinase)
Genetic testing - confirmatory
Complication → AKI
Tx:
Avoid hypoglycemia
Enzyme replacement therapy
Tx of complications
Fructosemia D&T
Genetic testing - confirmatory
Management: complete avoidance of fructose and sucrose
Galactosemia Dx
GALT enzyme def included in newborn
screening (WV)
RBC galactose-1-phosphate: ↑ in GALT def
GALT enzyme activity - ↓ in GALT def
Galactosemia Tx
Minimize dairy galactose
d/c breastfeeding/formulas
Use soy-based formulas (Alsoy, Isomil ProSobee)
Later avoid dairy products
Amino Acid Disorders Dx & Tx
Dx
Newborn screening (all states)
↑ plasma phenylalanine
Tx
* Dietary restriction of phenylalanine (avoid meat, dairy, nuts, aspartame)
* Supplement tyrosine
* Sapropterin (Kurvan) - adults/peds - activates PAH to promote breakdown of phenylalanine
* (only use if pt still as enzyme)
* Pegvalisale (Palyniq) - adults ONLY - degrades phenylalanine
like peg adults only- degrades like bdsmn lannisters
sap-rope-turn like a funnel cake is sticky like sap and twisty
Maple Syrup Disease D&T
Dx: Newborn screening
Prenatal screening
Tx:
* Dietary management - strict protein restriction
* Medical grade formula/food; Trial of thiamine supplement - 4wks
* Control metabolic decomposition: lower BCAA levels via hemodialysis
* Inhib further protein catab and enhance protein synth: d/c protein intake x 24-48hrs
* IV glucose - provides calories (prevents protein catab for energy)
* IV insulin if glucose is > 130mg/dL - insulin enhances endogenous protein synth
* Liver transplant - last resort
Homocystinuria Dx and Tx
Dx:
Newborn screening - ALL states
↑ homocysteine and methionine in plasma of urine
Tx:
* Dietary modification - protein restriction
* Vitamin B6, B12, folate supplements (helps convert homocysteine → methionine)
* Supplement cysteine
* Betaine (Cystadane) - helps convert
* homocysteine → methionine
be tame for home w mom
Types of glucosphinolipids
part of cell wall. protect from degrading enzymes
Types of glycosphingolipids:
Gangliosides - Tay-Sachs Dz
Cerebrosides - Gaucher Dz
Globotriaosylceramide - Fabry Dz
Sphingomyelin - Niemann-pick Dz
Gaucher Disease Dx
Newborn screening (handful of states)
Low beta-glucosidase leukocyte enzyme activity
Genetic testing - confirmatory:
Rec in Ashkenazi Jews
Prenatal testing possible
Gaucher Disease tx
Enzyme-replacement therapy (ERT) w/
recombinant glucocerebroside (Imiglucerase)
Helps breakdown glucocerebroside
NOT effective in ↓ CNS s/s
Substrate-reduction therapy (SRT):
Blocks prod of glucocerebroside
Eliglustat (Cerdelga) and miglustat (Zavesca)
a gausher surrounded can an igloo
Tay Sachs Disease Dx and Tx
Dx
* Genetic counseling
* Newborn screening (WV), pregnancy screening
* Hex A enzyme analysis - low level
Tx
Supportive care
s/s control
Manage inf
Prevent complications → OT, feeding tube
Prevention:
Carrier screening, genetic counseling (esp
Ashkenazi Jews, French-Canadians, Cajuns)
Emerging - Hex A enzyme replacement tx,
substrate reduction tx
Fabry Disease Dx and Tx
Dx
* GLA enzyme activity ↓
* Confirm w/ genetic testing
Tx
* Enzyme-replacement - cornerstone of tx
* Agalsidase beta (Fabrazyme)
* Chaperone tx - migalastat (Galafold)
MOA: ↑ GLA enzyme activity preventing
accumulation of GL3 (adults ONLY)
Control neuropathic pain
Stroke prevention (ASA + Clopidogrel, antiHTN, statins)
A gal said my gala stat needs a chaperone. fairies have gallas
Niemann-pick disease Dx and Tx
Dx
* Newborn screening (NOT in WV)
* Genetic testing
Tx
* ERT for NPD Type B - olipudase alfa-rpcp (Xenpozyme)
* NO ERT is FDA-approved for Type A or C
* Supportive care - PT/OT, feeding tube
- O2 tx and blood transfusion; avoid contact sports if splenomegaly
play with pudding in the tub
Pompe Disease Dx and Tx
Dx:
* Newborn screening (NOT in WV)
* Acid α-glucoside (GAA) levels ↓
* Genetic testing confirms dx
* Prenatal screening
Tx
* Enzyme replacement therapy - alglucosid- α (Lumizyme)
* Monitor - risk of gradual weakness, fractures, dysphagia, sleep apnea
alglucosid-a = algorythm cheer speech
Hyperphosphatemia tx only
- Acute severe dz - IV fluids if no CKD
- Hemodialysis if CKD
- Mild dz - dietary restrictions (avoid dairy, meats, beans)
Mod-severe - phosphate binders:
* Calcium acetate (PhosLo)
* Lanthanum carbonate ( Fosrenol)
* Sevelamer (Renagel)
Hypophosphatemia tx
Treat underlying disorders
- Avg pt req 1-2g of phosphate per day for 7-10days to replenish body stores
- Mild hypoP - ↑ dietary phosphate intake (dairy, meats, beans)
- Mod-severe hypoP - phosphate supplement (Na or K Phosphate)
1g/d for a week.
mild fix with diet
severe fix with supplement
Phosphorus supplement
Na or K phosphate in capsule or liquid
AE: weakness, N/V/D, abd pain, brady,arrhythmia
CI: hyperP, severe renal imp, hyperK
Safe in pregnancy
Hypomagnesemia tx
↑ dietary Mg - dark green veggies, legumes (beans/peas), nuts, seeds, whole, unrefined grains
Pharm replacement:
Severe (tetany, arrhythmias) - 50mEq of IV Magnesium
Mild-Mod - PO Magnesium
Replenish Ca and K if indicated
Phosphate binders
indicates in ESRD on dialysis
when you have too much phosphorus and you need to get rid of it
Paget Disease Dx Tx
Dx
* * ↑ alkaline phosphate and bone-specific
* alkaline phosphate (BSAP)
* XRAY:
* Early dz - lytic lesion
* Later dz - lytic lesions and excessive bone formation
* Radionucleotide bone scan - determines extent of dz
Tx
* Bisphosphates - inhib osteoclast activity
* Alendronate (Fosamax)
* ibandronate (Boniva)
* risedronate (Actonel)
* zoledronic acid (Reclast)
* NSAIDs for joint pain
* Ca and Vit. D supplement