Endo Flashcards
What is diabetes insipidus?
Lack of ADH production or lack of response to it
Prevents kidney from concentrating the urine leading to polyuria and polydipsia
What are the causes of diabetes insipidus?
Nephrogenic - drugs especially lithium, mutations in the AVPR2 gene for ADH receptor, intrinsic kidney disease, hypokalaemia, hypercalcaemia
Cranial - idiopathic, brain tumour, head injury, brain malformation, brain infection, brain surgery or radiotherapy
Signs and symptoms of diabetes insipidus
Polyuria, polydipsia, dehydration, postural hypotension, hypernatraemia
Investigations for diabetes insipidus
Urine test to check osmolality - would be low
Serum osmolality - would be high
Water deprivation test - no fluid for 8 hours, measure urine osmolality, then give desmopressin. Measure urine osmolality after 8 hours again. In cranial osmolality will go up, in nephrogenic it’ll stay low.
How to manage diabetes insipidus
Treat underlying cause
Desmopressin for cranial diabetes insipidus
High dose desmopressin and thiazides diuretic for nephrogenic
What is Cushing’s syndrome? How is it different to Cushing’s disease?
signs and symptoms that develop as a result of abnormal elevation of cortisol
- the disease is specifically when it’s caused by a pituitary adenoma secreting excessive ACTH
Aetiology/risk factors for Cushing’s syndrome
- exogenous steroids
- Cushing’s disease
- Adrenal adenoma
- Paraneoplastic Cushing’s (excessive ACTH released from a cancer other than the pituitary, usually small cell lung cancer)
Presenting signs and symptoms of Cushing’s syndrome
- central obesity
- fatigue
- muscle weakness
- hirsutism
- acne
- moon face
- thin skin
- poor wound healing
- buffalo hump (fat pad on upper back)
- bruises
- hypertension
- cardiac hypertrophy
- hyperglycaemia
- depression
- insomnia
- pink striae on abdomen/breasts/thighs
Investigations for Cushing’s syndrome
- Blood test to confirm hypokalaemic metabolic alkalosis
- Dexamethasone suppression test, no suppression of morning cortisol (low dose 1mg, then high dose 8mg)
- 24hr urinary free cortisol is alternative to suppression test
- MRI for pituitary adenoma
- Chest CT for lung cancer
- Abdominal CT for adrenal tumours
How can we use the dexamethasone suppression test to find the cause of Cushing’s syndrome?
- confirm Cushing’s with low dose test
- Cushing’s disease, the 8mg will suppress cortisol due to negative feedback so low cortisol and low ACTH
- Adrenal adenoma, the 8mg doesn’t affect the cortisol release from the tumour but it will suppress the ACTH release from the pituitary so low ACTH, high cortisol
- in ectopic ACTH release, the cortisol will be high and ACTH will be high
How is Cushing’s syndrome treated?
- treat the underlying cause
- remove the tumour
- use metyrapone or ketoconazole to inhibit cortisol synthesis (if unfit for surgery or pre-operatively)
- trans-sphenoidal removal of pituitary adenoma
- surgical removal of adrenal tumour
- surgical removal of tumour producing ectopic ACTH
- radiotherapy after surgery if not cured
- replacement steroids for life is both adrenals need to be removed
Possible complications of Cushing’s syndrome
- diabetes
- osteoporosis
- hypertension
- pre-disposition to infections
- surgery complications:
- CSF leakage
- meningitis
- sphenoid sinusitis
- hypopituitarism
What is hyperthyroidism and what are the different causes?
- over-production of thyroid hormone
- Primary is due to thyroid pathology
- Secondary is due to pituitary or hypothalamus pathology
- Grave’s disease is autoimmune disease where TSH receptor antibodies cause primary hyperthyroidism
- Toxic multinodular goitre (Plummer’s) is where nodules of thyroid gland act independently of the normal feedback system
- Thyroiditis
What are the universal features of hyperthyroidism?
- anxiety and irritability
- sweating and heat intolerance
- tachycardia
- weight loss
- fatigue
- frequent loose stools
- sexual dysfunction
Unique features of Grave’s disease
All due to presence of TSH receptor antibodies
- diffuse goitre
- exophthalmos
- pretibial myxoedema