Derm Flashcards
What is urticaria?
Small, itchy lumps that appear on the skin which may be associated with patchy, erythematous skin.
Acute or chronic
Common causes of acute urticaria
Triggered by anything that causes mast cells to release histamine
Allergies to food, medication or animals
Chemicals, latex, stinging nettles
Medications
Viral infections
Insect bites
Causes of chronic urticaria
Autoimmune disorder where antibodies target mast cells to release histamine
Chronic inducible is recurrent urticaria which is caused by certain triggers such as sunlight, temperature change, exercise, strong emotions, hot or cold weather
Chronic idiopathic has no clear cause
Autoimmune urticaria is associated with an underlying autoimmune condition such as SLE
How is urticaria managed?
Antihistamines: fexofenadine for chronic, oral steroids for short severe flare
If very problematic and severe then consider anti-leukotrienes, omalizumab or cyclosporin
What is eczema?
chronic atopic condition caused by defects in the normal continuity of the skin barrier, leading to inflammation
Where does eczema usually occur?
flexor surfaces (inside of elbows and knees)
How should eczema be managed?
- maintenance and management of flares
- maintenance = emollients used often, avoid soaps and body washes
- manage flares = topical steroids
What are some complications of eczema?
- bacterial infection caused by infective organism, usually staphylococcus aureus
- eczema herpeticum caused by HSV or varicella zoster
What is psoriasis?
- chronic autoimmune condition that causes recurrent symptoms of psoriatic skin lesions
- usually dry, flaky, scaly, erythematous skin lesions on knees, elbow or scalp
What are the different types of psoriasis?
- Plaque = thickened erythematous plaques with silver scales
- Guttate = children, small raised papules across trunk and limbs, usually triggered by streptococcal throat infection, stress or medications
- Pustular = pustules form under areas of erythematous skin
- Erythrodermic = erythematous inflamed areas covering most of the surface of the skins
How does psoriasis present in children?
- guttate in children, often triggered by a throat infection
Signs of psoriasis
- Auspitz = small points of bleeding when plaques are scraped off
- Koebner phenomenon = development of psoriatic lesions of skin affected by trauma
- Residual pigmentation = after lesion resolves
How should psoriasis be managed?
- topical steroids
- topical vitamin D analogues
- topical dithranol
- topical tacrolimus
- phototherapy with ultraviolet B light
What are the associations of psoriasis?
- Nail psoriasis = pitting, thickening, discolouration, ridging, onycholysis
- Psoriatic arthritis
- Psychological implications
What is cellulitis? What usually causes it?
bacterial infection of the deep dermis and subcutaneous tissue, usually lower limb
- Streptococcus pyogenes and staphylococcus aureus but also Streptococcus pneumoniae, Haemophilus influenzae