Emergency Flashcards
Features of serotonin syndrome?
Myoclonus is most specific feature
- Autonomic hyperactivity: HYPERTENSION, tachycardia, diaphoresis, hyperthermia (can be >41°C), diarrhoea/ GI motility, Sialorrhoea (inability to control oral secretions)
- Neuromuscular abnormalities: Hyperreflexia, myoclonus, ocular clonus, tremor
- Mental state changes: agitation, confusion, hyperactivity
Features of anticholinergic toxidrome?
“mad as a hatter” - altered mental state
“blind as a bat” - dilated pupils
“red as a beet” - flushed skin
“hot as a hare” - hyperthermia
“dry as a bone” - dry skin, urinary retention
absent bowel sounds
tachycardia
How does anticholinergic toxidrome differ from serotonin syndrome, NMS
No clonus or hyperreflexia
Dry skin
Absent bowel sounds
Management of anticholinergic toxidrome?
IVT
Diazepam
Anticholinesterase inhibitor
Toxidrome seen with organophosphate poisoning (or mushrooms)?
Cholinergic toxidrome
Features of cholinergic toxidrome?
Diarrhoea
Urination
Miosis (constricted)
Bronchorrhoea
Bronchospasm
Emesis
Lacrimation
Salivation
Management of cholinergic toxidrome?
Atropine
IVT
consider IDC
Diazepam for seizures??
Pralidoxime can bind organophosphates
Features of opioid intoxication
CPR 3H
Coma
Pinpoint pupils
Resp depression
Hypotension
Hypothermia
Hyporeflexia
Paracetamol dose that may be associated with hepatic injury?
> 200mg/kg or 10g over a period of <8hrs
(or repeated ingestion of same over a 24hr period)
When can charcoal be used in paracetamol OD?
<4hrs of SR overdose or <2hrs of IR overdose
Child presents post paracetamol OD, When should paracetamol level be taken?
2hrs for liquid
4hrs for tablet
Examples of “one pill can kill” drugs
Alpha adrenergics eg clonidine
Sulfonylureas
Calcium channel blockers
Beta blockers
Opioids
Salicylates
Amphetamines
Agents which DON’T bind well to charcoal
Iron
Lithium
Ethanol/methanol
Potassium, Lead, Arsenic, Mercury
Corrosives
Indications for whole bowel irrigation (in overdose)
- Iron overdose >60mg/kg
- Slow release KCl
- SR Verapamil or diltiazem
- Lead ingestion
Typical blood volume of an infant?
80ml/kg
(child >1yr = 70ml/kg)