Embryonic development

Question 1

Where do sclerotomes develop from?

Answer 1

Pad axial mesoderm -> somites -> sclerotome

Question 2

What does the dense caudal section of the sclerotome form?

Answer 2

Neural arch and intervertebral disc

Question 3

What does the diffuse cranial section form?

Answer 3

Vertebral body

Question 4

How do vertebra form?

Answer 4

1. Sclerotome split into caudal and cranial sections. Caudal of one combines with cranial of another to form hemivertebra
2. Neural arch is formed from caudal sections and encloses the neural tube. Fuses dorsally to form the vertebral foramen
3. Vertebral body arises from the cranial section. Is obliterated when fuses
4. Notochord remains in spaces between vertebra. Incorporated into intervertebral discs as nucleus pulposus

Question 5

How many sclerotome a form one vertebra?

Answer 5

4

Question 6

What are the 3 centres of ossification of vertebral bodies?

Answer 6

Body, cranial end plate, caudal end plate