Embryology of the Urinary System Flashcards
When does the development of the urinary system begin?
During week 4
Where does the urinary system develop from?
The urogenital ridges in the intermediate mesoderm on either side of the primitive aorta
What are the three overlapping systems that the kidneys develop from?
The pronephros, mesonephros and metanephros
Where does development of the pronephros begin?
The cervical region of the embryo
What system do the nephrotomes belong to?
The pronephros
What are the nephrotomes?
Segmented divisions of intermediate mesoderm = between 6 and 10 pairs are formed in total
What structure do the nephrotomes join with?
Join into the pronephric duct
What is the pronephric duct?
Duct that extends from the cervical region to the cloaca of the embryo
What is the fate of the pronephros?
Non-functional and regresses completely by the end of week 4
Where does the mesonephros develop?
Caudally to the pronephros
What does the presence of the pronephric duct induce in the mesonephros?
Induces the nearby intermediate mesoderm in the thoracolumbar region to form mesonephric tubules
How is filtration of blood by the mesonephros facilitated?
Mesonephric tubules receive a tuft of capillaries from the dorsal aorta
Where do the capillaries that supply the mesonephric tubules drain into?
The mesonephric duct = continuation of the pronephrotic duct
What do the mesonephric tubules act as?
A primitive excretory system = most tubules regress by end of month 2
What structure does the mesonephric duct give rise to?
Sprouts the ureteric bud caudally, which induces the development of the definitive kidney
What does the metanephros form?
The definitive kidney
When does the metanephros begin to develop?
Appears in week 5 and becomes functional around weeks 9-11
What are the components of the metanephros?
Ureteric bud and the metanephric blastema = consists of a collecting system and an excretory system
Where is the collecting system of the metanephros derived from?
The ureteric bud
What does the collecting system of the metanephros go on to form?
Dilates to create the ureter, renal pelvis, major and minor calyces, and collecting tubules