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Respiratory System > Embryology > Flashcards

Embryology Flashcards

1
Q

What is gametogenesis?

A

Formation of the gametes in the gonads where germ cells first under go mitosis to increase cell numbers to form:

Speratogonium
Oogonium

Both 46 chromosome

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2
Q

Explain process of spermatogenesis

A

After birth, the testes of newborns males haven’t progressed passed mitosis. After birth, the gonads are inactive until puberty where the spermatogonia undergo meiosis to form 4 haploid gametes

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3
Q

Explain process of oogenesis

A

At birth, oogonia have complete oogenesis and meiosis to produce 3 degenerate ova, polar bodies and one haploid ovum

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4
Q

Explain process of fertilisation

A
  1. Ovum swept into Fallopian tube by beating cilia
  2. Sperm surrounds ovum, but only one penetrated
  3. The (pro)nucleus of sperm enters and fuses with the (pro)nucleus of the ovum
  4. Forms a diploid zygote
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5
Q

What is a morula?

A

A solid mass of cells formed when the zygote divides by mitosis

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6
Q

What does the morula become and why?

A

Becomes a blastocyst as it must alter structure as the large number of cells in the morula mass means it is hard to get nutrition to the centre

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7
Q

How does the blastocyst form from the morula?

A
  1. A blastocystic cavity forms as cells accumulate to one end
  2. Accumulation of cells = Inner cell mass
  3. the outer lining of cells around perimeter = trophoblast
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8
Q

How long does the first division of the zygote take in becoming a blastocyst?

A

36 hours

2nd - 24hr
3rd - 12 hours

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9
Q

Name a maternally inherited mitochondrial disease which causes blindness

A

Leber’s hereditary Optic Neuropathy

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10
Q

What is a chorion?

A

Developed from the trophoblast, of the blastocyst, which decided into two layers which form the chorion

The chorion develops process; chorionic villi

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11
Q

What is an ectopic pregnancy?

A

When the embryo implants abnormally outside the womb, usually in the fallopian tubes. Can be dangerous, and usually due to abnormal cilia function

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12
Q

What is the chorions function?

A

Implantation process
Forms part of the placenta
Secretes Human Chorionic Gonadotropin (HCG) - used to detect pregnancy

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13
Q

What does human chorionic gonadotropin (HCG) do?

A

It’s a hormone which stimulate the ovaries to produce oestrogen and progesterone, to keep the endometrium intact

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14
Q

What is the decidua basalis?

A

Part of endometrium deep to the implanted conceptus, where the maternal side of the placenta is found

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15
Q

Chorion roll in the implantation process

A
  1. Implants blastocyst into endometrium
  2. enzymes from villi breakdown maternal blood vessels
  3. Forms part of the placenta
  4. Secrete HCG to maintain endometrium
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16
Q

What two cavities are formed following the formation of the bilaminar disc in the embryo?

A 
Amniotic sac (above epiblast)
Yolk sac (below hypoblast)
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17
Q

What is the function of the allantoic cavity?

A

Gas exchange and removal of liquid waste - later forms the urinary bladder

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18
Q

What are the 3 main functions of the placenta?

A

Foetal nutrition
Transport of waste and gases
Immune protection

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19
Q

Describe the foetal part and surface of the placenta

A

Smooth with foetal blood vessels and end of umbilical cord

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20
Q

Describe the maternal part and surface of the placenta

A

Decidua basalis of endometrium - rough and has maternal blood vessels

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21
Q

When does the placenta become fully mature?

A

18-20weeks

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22
Q

Describe fraternal/dizygotic multiple births

A

Comes from two separate zygote after two ova are released - genetically unique and have own placenta

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23
Q

Describe identical/monozygotic twins

A

One zygote is formed which divides into two and each cells develops into a different embryo - same genetic material and share one placenta

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24
Q

What occurs in week 3?

A

Gastrulation
Neurulation
Development of smites
Early CVS

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25
Q

What is gastrulation?

A

Formation of germ layers

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26
Q

What is neurulation?

A

Formation of neural tube

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27
Q

Where does the primitive streak form?

A

Formed in the midline of the epiblast by the dipping in of cells (invagination)

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28
Q

What happens in gastrulation?

A

Cells of the epiblast migrate down into the space between the epiblast and the hypoblast, and keeps dividing until they displace the hypoblast cells

This forms 3 germ layers and the trilaminar disc:

  1. Ectoderm
  2. Mesoderm
  3. Endoderm
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29
Q

What are the cells in the trilaminar disc specialised to eventually become?

A

Ectoderm - nervous tissue
Mesoderm - bone, cartilage and skeletal muscle
Endoderm - epithelial lining

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30
Q

What is the notochord?

A

Sends out signals which are picked up by receptors to initiate cell differentiation to form he neural tube

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31
Q

How is the notochord formed?

A

Cells in the primitive streak sink down to in between the mesoderm and the endoderm

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32
Q

Describe stages in neurulation

A
  1. Notochord signal ectoderm to form neural plate
  2. Dip forms in the plate which deepens
  3. Two end of dip join to form a tube and loses connection with ectoderm
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33
Q

What will the neural tube eventually form?

A

The brain and spinal cord at the dorsal end of body

34
Q

What is the neural tubes affect on the mesoderm?

A

It induces the mesoderm to thicken

35
Q

What are the 3 parts that the mesoderm separate into?

A

Paraxial
intermediate plate
Lateral plate: this divides further into somatic and splanchnic with the space in between called the intraembryonic coelom

36
Q

What are the 3 mesoderm parts specialised to form?

A

Paraxial -> somites
Intermediate plate -> urogenital system (kidneys + reproductive)
Lateral -> body cavity and coverings

37
Q

How many pairs of somites are there?

A

43

38
Q

Describe folding of the embryo

A

Folding occurs in the transverse plane and sagittal plane due to differing rate of growth of structures - occur simultaneously

39
Q

Describe lateral folding

A

The two ends join
Endoderm becomes innermost tube (gut tube which has connection to yolk sac)
Ectoderm surrounds outside

40
Q

What happens to each somite and the fate of each?

A

Each somites separate further into three:

Dermatome -> dermis of skin
Myotome -> muscles
Sclerotome -> bones including vertebrae

41
Q

What are teratogens?

A

Environmental factors that cause abnormal development as they’re able to cross the placenta

42
Q

Name 2 examples of teratogens

A

Maternal measles -> congenital rubella syndrome

Thalidomide use -> malformed limbs

43
Q

Give examples of environmental factors with can teratogens

A

Drugs
Alcohol/tobacco
Infectious agents: toxoplasma, rubella, cytomegalovirus, herpes (ToRCH)
Others - radiation

44
Q

Give examples of genetic factors which cause abnormal development of embryo

A

Too many/few - turner’s, Down’s syndrome

Structural - deletions of genes

45
Q

What period of embryo development is most sensitive to teratogens?

A

Weeks 3-8

46
Q

What does the risk of teratogens depend on?

A

Critical periods of development
Dosage of drug/chemical/factor
Genetic constitution of embryo (some more susceptible than others)

47
Q

What are the three parts to the gut tube formed by the endothelium?

A

Foregut
Midgut
Hindgut

48
Q

What do the trachea and lungs form from?

A

The ventral wall of the foregut

49
Q

At what week of development do the trachea and lungs begin to form?

A

4 weeks of gestation

50
Q

Describe first stages of the respiratory primordium

A

Starts as a median outgrowth as the laryngotracheal groove (diverticum) form the ventral part of the foregut

51
Q

What happens to the diverticulitis after its outgrowth?

A

Become invested with mesoderm and enlarges to form trachea and lung buds

52
Q

What is the oesophagotracheal septum?

A

The septum that develops and separate the oesophagus and trachea

53
Q

What is a fistula?

A

An abnormal or surgically made passage between a hollow tube and the body surface, or between two hollow tubes

I.e. between two epithelialised surfaces

54
Q

What is atresia?

A

A condition in which an orifice or passage in the body is closed or absent

55
Q

What is a tracheoesophageal fistula (TOF)?

A

The abnormal connection between the trachea and oesophagus

56
Q

Where can atresia occur?

A

Can occur in the oesophagus, where the tube doesn’t lead to stomach, but ends, and there is a connection between the trachea and rest of oesophageal tube to stomach (fistula)

57
Q

Where do the somatic and splanchnic mesoderm originate from?

A

Lateral plate mesoderm

58
Q

What mesoderm does the visceral pleura develop form?

A

Splanchnic mesoderm

59
Q

What mesoderm does the parietal pleura develop from?

A

Somatic mesoderm

60
Q

What is the space in-between the pleura called initially?

A

Pleuroperitoneal canals

61
Q

What develops to separate the pleural cavity from the pericardial cavity?

A

Pleuropericardial folds

62
Q

What are the 4 key stages during the differentiation of the lung buds?

A
  1. Pseudoglandular
  2. Canalicular
  3. Saccular
  4. Alveolar
63
Q

When does the pseudoglandar stage occur and what happens?

A

1-17weeks

Set up of all pulmonary structures except elements needed for gas exchange

64
Q

When does the canalicular stage occur and what happens?

A

17-27 weeks
The terminal bronchioles gives rise to tubes that make up the respiratory part of the lung
Differentiation of epithelium into cuboidal secretory cells (Type II penumocytes) which will produce surfactant and flat cells (Type I)

65
Q

When does the saccular stage occur and what happens?

A

27-40 weeks

Formation of alveolar sacs

66
Q

When does the alveolar stage occur and what happens?

A 
Post-natal: 32 - 8 years
Formation of alveoli from terminal sacs 
95% of alveoli formed postnatally 
Alveoli enlarge 
Number of respiratory bronchioles (and alveolar ducts and alveoli) increased as lungs increase, and adult size around 8yrs
67
Q

What is Respiratory Distress Syndrome (RDS)?

A

Lungs are deficient in surfactant, which prevents their proper expansion and causes the formation of hyaline material in the lung spaces.

68
Q

What is a major cause of RDS?

A

Surfactant deficiency

69
Q

What are other congenital conditions of the lung?

A

Presence of accessory lobe
Lobe of azygous vein
Agenesis of lung

70
Q

What is he lobe of the azygous vein?

A

Congenital condition where the azygous vein embeds itself into the R Lung, making it look like there’s an extra lobe

71
Q

What is anagenesis of the lung?

A

Congenital condition where the lung didn’t develop

72
Q

What are the four embryonic components that form the diaphragm?

A
  1. Septum transverse
  2. Pleuroperitoneal membrane
  3. Dorsal mesentery of oesophagus
  4. Muscular growth from lateral body walls
73
Q

What does the septum transversum form in the diaphragm?

A

Central tendon

74
Q

What does the pleuroperitoneal membrane form in the diaphragm?

A

Primitive diaphragm

75
Q

What does the dorsal mesentery of oesophagus form in the diaphragm?

A

Median portion and crura of diaphragm

76
Q

What does the muscular ingrowth from the lateral walls form in the diaphragm?

A

Peripheral parts of the diaphragm

77
Q

Why is the diaphragm innervated by spinal nerves C3, 4, 5 when it is located lower in the adult body?

A

As the septum transverse was initially located opposite C3-5 somites then migrated down caudally during diaphragm development, bringing C3, 4, 5 with it

78
Q

What are the congenital abnormalities associated with diaphragm development?

A 
Failure of the diaphragm to completely close during development 
Herniation of the abdominal contents into the chest 
Pulmonary hypoplasia (incomplete development of the lungs)
79
Q

What is a hernia?

A

Term used to describe a bulge or protrusion of an organ through the structure or muscle that usually contains it

80
Q

What are three different types of diaphragmatic herniae?

A

Posterolateral
Anterior
Central

81
Q

What are the two types of hiatal herniae?

A

Sliding: stomach through to oesophagus
Paraoesophageal: stomach slides up parallel to oesophagus

Respiratory System (29 decks)

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