Embryology Flashcards
Deep midline gash that becomes the oral cavity
Stomodeum
Bilateral growth of embryonic tissue in the ventro-lateral region of the head
- 5 pairs of pharyngeal arches form in cranial to caudal sequence
Pharyngeal Apparatus
Pharyngeal arches are separated by ___________ on the outside
pharyngeal grooves/clefts
Direction of formation of pharyngeal arches
cranial to caudal
Pharyngeal arch formation is primarily driven by __________________
the migration and proliferation of neural crest
The two sub-prominences of the first pharyngeal arch
maxillary and mandibular prominence
Most of the pharyngeal clefts close/smooth over in order to provide a smooth neckline; however, the first pharyngeal cleft becomes the ___________
external auditory meatus
The oralpharyngeal membrane is ____________ to the stomodeum
posterior
The external auditory meatus is left over from which pharyngeal cleft?
first pharyngeal cleft
Are the pharyngeal clefts numbered according to the arches above or below them
above
Around week _________ the oralpharyngeal membrane perforates to allow for the tongue and other structures to develop into the primitive oral cavity
3 to 4
The pharyngeal arches mainly arise from proliferating / migrating neural crest cells.
How many distinct streaks migrate and in which direction do the travel?
5 streaks
Migrating ventrally
Pharyngeal arch outside covering?
Ectoderm
Pharyngeal arch inside lining
Endoderm
- Note: arch 1 is covered mostly by ectoderm on the inside -> oral ectoderm
Core of each arch - composition
mesenchyme
The core of pharyngeal arch is mesenchyme. What makes up the major component of the mesenchyme
neural crest
Neural crest cells make up the majority of the mesenchyme of the core of the pharyngeal arch - what structures do these neural crest cell give rise to?
Cartilage and Bone
In addition to neural crest cells, what else comprises the core of pharyngeal arches?
Mesoderm (paraxial) –> skeletal muscles
Nerve (V, VII, IX, X)
Blood vessel
Skeletal muscle of the face comes from?
Paraxial plate mesoderm
mesoderm balls up into somites which differentiate into myotomes - myotomes then migrate to provide skeletal muscle :
The first arch is subdivided into the ___________ prominence cranially, and into the __________ prominence caudally
cranially - maxillary
caudally - mandibular
First arch
Cranial Nerve ____
V
First arch - maxillary prominence
Cranial Nerve ___
V2 (maxillary)
First arch - mandibular prominence
Cranial Nerve ___
V3 (mandibular)
The maxillary nerve is associated with which pharyngeal arch
1
The mandibular nerve is associated with which pharyngeal arch
1
The facial nerve is associated with which pharyngeal arch
2
The vagus nerve is associated with which pharyngeal arch
4/6
The glossopharyngeal nerve is associated with which pharyngeal arch?
3
Do pharyngeal arches receive a common blood vessel supply?
No… each pharyngeal arch has its own blood vessel supply
All of the myotomes of 1st pharyngeal arch - mandibular prominence have ________ nerve innervation
mandibular (V3)
All of the myotomes of 1st pharyngeal arch - maxillary prominence have ________ nerve innervation
maxillary (V2)
All of the myotomes of the 3rd pharyngeal arch have _______ nerve innervation
glossopharyngeal
All of the myotomes of the 4/6 pharyngeal arch have _________ nerve innervation
vagus
All of the myotomes of the 2nd pharyngeal arch have ________ nerve innervation
facial
Mesenchyme (embryonic CT) can come from ectoderm, endoderm, neural crest…
In the pharyngeal arches, which germ layer comprises the mesenchyme
neural crest
We retain the first pharyngeal membrane as __________
the tympanic membrane
Separates pharyngeal arches from the outside
pharyngeal groove / cleft
Pharyngeal groove / cleft is lined by?
ectoderm
Separates pharyngeal arches from the inside
pharyngeal pouch
pharyngeal pouches are lined by
endoderm
Where ectoderm and endoderm come together at pharyngeal cleft/grooves
pharyngeal membrane
Pharyngeal arch 1
- -> Neural crest derivatives
- —-> Maxillary Prominence
Maxillary bone
Zygomatic and squamous portions of temporal bone
Pharyngeal arch 1
- -> Neural crest derivatives
- —-> Mandibular Prominence
Meckel's cartilage (embyro) Mandible Malleus Incus Anterior ligament of Malleus
Pharyngeal arch 2
–> Neural crest derivatives
Reichert Cartilage (embryo) Lesser cornu of hyoid (superior hyoid) Stylohyoid ligament Styloid process Stapes
Pharyngeal arch 2 is associated with which cranial nerve?
Facial (VII)
Pharyngeal arch 3
–> Neural crest derivatives
Body of hyoid
Greater Cornu of Hyoid
(Collectively inferior hyoid)
Pharyngeal arch 4/6
Thyroid and Cricoid cartilage of larynx (laryngeal cartilages)
Arches develop from _______ to _________ direction
cranial to caudal
Pharyngeal arch 1
–> mesoderm derivatives
Muscles of mastication: - temporalis - masseter - medial pterygoid - lateral pterygoid mylohyoid ant. belly digastric tensor tympani
Innervation of first pharyngeal arch (cranial nerve)?
trigeminal
Pharyngeal arch 2
–> mesoderm derivatives
muscles of facial expression
stylohyoid
posterior belly digastric
Innervation of the second pharyngeal arch? (CN)
Facial (VII)
Pharyngeal arch 3
–> mesoderm derivatives
stylopharyngeus
Innervation of third pharyngeal arch? (CN)
glossopharyngeal
Pharyngeal arch 4&6
–> mesoderm derivatives
pharyngeal constrictors
soft palate muscles
laryngeal muscles
Innervation of 4/6 pharyngeal arch? (CN)
vagus
Pharyngeal arch 1
Motor Innervation
Muscles of mastication
ant bell of digastric
tensor tympani
Pharyngeal arch 1
Sensory innervation
somatosensation
- face
- teeth
- anterior 2/3 tongue
- palate
Which pharyngeal arch provides taste sensation to anterior 2/3 tongue?
Pharyngeal arch 2
facial
Does pharyngeal arch 2 contribute sensation to tongue?
ONLY special sensory (taste)
NOT somatosensory
(Pharyngeal arch 1 and 3 are responsible for ant 2/3 and post 1/3 of tongue’s somatosensation, respectively)
Pharyngeal arch 2
Motor innervation
Muscles of facial expression
Posterior belly digastric
stylohyoid
Pharyngeal arch 2
Sensory innervation
special sensory (taste) for anterior 2/3 tongue NO somatosensory