Embryology Flashcards

1
Q

which primitive layer do the urinary and reproductive systems develop from

A

the intermediate mesoderm

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2
Q

which ridge does the urinary tract develop from

A

nephrogenic

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3
Q

what ridge does the reproductive system develop from

A

gonadal ridge

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4
Q

What are the 3 stages of kidney development

A

pronephros
mesonephros
metanephros

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5
Q

when do pronephros form and when fo they degenerate

A

form in cervical region during week 4 and degenerate by the end of the week

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6
Q

where and when do mesonephros form

A

thoracic and upper lumbar regions- interim kidney until month 3
meonephric tubules develop and drain into wolffian duct of mesonephric duct which drains to cloaca

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7
Q

when do metanephros form

A

during week 5 and functional by end of 3rd month

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8
Q

what does the metanephric blastema form

A

intermediate mesoderm that forms excretory units- nephron like bowmands capsule, proximal convoluted tubules, loop of hence and distal convuluted tubules

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9
Q

what does the ureteric bud form

A

evagination of mesonephric duct, penetrates blastema and forms the duct system of collecting tubules, minor and major calyces and renal pelvis and ureter

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10
Q

Where do the kidneys form and when do they migrate

A

form in pelvis and ascend around week 9 to abdomen

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11
Q

do the kidneys lay in their original position when the ascend

A

they rotate about 90 medially

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12
Q

What does the urorectal septum divide

A

the cloaca into anterior urogenital sinus and posterior rectum/anal canal

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13
Q

What arises from the urogenital sinus

A

bladder and parts of urethra

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14
Q

what arises from the cranial portion of urogenital sinus

A

bladder and the urachus which forms median umbilical ligament

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15
Q

what forms the trigone region of urinary bladder

A

mesonephric duct

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16
Q

what does the middle portion (pelvic) of the urogenital sinus form in females? in males?

A

females it becomes the urethra

males it becomes the prostateic and membranous urethra

17
Q

what forms from the caudal (phallic) portion of the urogenital sinus

A

males only- penile urethra

18
Q

What arises from persistence of caudal renal aa during development

A

accessory renal aa that usually are asymptomatic but can compress ureter and cause hydronephrosis

19
Q

What causes renal hypoplasia

A

inadewuate branching of ureteric bud and lack of differentiation of nephrons.

20
Q

What is a types of renal hypoplasia

A

persistent fetal lobulation

21
Q

What happnes in congenital cystic kidney disease whenn it is autosomal recessive

A

cysts form from collecting ducts- renal insufficiency

22
Q

what happens in congenital cystic disease when it is autosomal dominant

A

cysts form from collecting ducts and nephron

23
Q

what are kidney cysts

A

wise dilations of parts of the nephrons

24
Q

what causes renal agenesis

A

ureteric bud fails to form and/or induce differentiation of the metanephric blastema
uni or bilateral

25
Q

what primarlily causes potter sequence

A

bilateral renal agenesis

26
Q

what does renal agensis resul in

A

oligohydramnios- fetus not urinating

27
Q

what are secondary symptoms to oligohydramnios

A

hypoplastic lungs
potter facies- broad, flat nose, wide-set eyes, low-set ears, micrognathia
sometimes limb malformations like club foot

28
Q

what is a horseshoe kidney

A

inferior poles fuse into pelvis and so ascent is blocked nu inferior mesenteric artery

29
Q

what are ectopic kidneys

A

kidneys fail to ascend

30
Q

What is the most comon malignant tumor of kidneys in children

A

wilms’ tumor present before age 5 due to muation in WT1 gene

31
Q

How does one get a suplication of one ureter

A

splitting of uteric bud- someitmes can cause 2 kidneys

32
Q

what is an ectopic ureter

A

two ureteric buds form and one is normal the other goes to abnormal site on bladder or urethra, vestibule, vagina

33
Q

What occurs when the lumen of the allantois persists

A

urachal anomalies like a fistula, a sinus or cyst

34
Q

what is a urachal fistual

A

entire lumen remains open so urine could leak from umbilicus

35
Q

What is exstophy of the bladder

A

ventral body wall defect because lateral body walls do not fuse causing the mucosa to be exposed and presents with epsipadias

36
Q

What is extrophy of the cloaca

A

ventral body wall defect when lateral body wall does not fuse causing inner epithelium to be exposed and the urorectal septum is also deficient causing exposure to rectum. imperforate anus

37
Q

what is more severe extrophy of bladder or cloaca?

A

cloaca