Embryology Flashcards
When does the pronephros appear?
Week 4, then degenerates
What is the Mesonephros?
Functions as interim kidney for 1st trimester
What does the Mesonephros become after?
Contributes to male genital system
What is the metanephros and when does it appear?
Permanent kidney that first appears in 5th week of gestation
How long does nephrogenesis continue through?
32-36 weeks of gestation
What is the ureteric bud derived from?
Caudal end of mesonephros
What does the ureteric bud give rise to?
Ureter
pelvises
calyces
collecting duct
When is the ureteric bud canalyzed by?
10th week
What interacts with the metanephric mesenchyme?
Ureteric bud
What does the interaction between the metanephric mesenchyme and the ureteric bud lead to?
Induces differentiation and formation of glomerulus through to distal convoluted tubule
Aberrant interaction between _____ and _______ may result in several congenital malformations of the kidney
Metanephric mesenchyme and ureteric bud
What is the last to canalize and most common site of hydronephrosis in the fetus?
Ureteropelvic junction
What happens in Potter’s syndrome?
Oligohydraminos–>
Compression of fetus–>
limb and facial deformities and pulmonary hypoplasia (cause of death)
Babies who can’t ______ in utero develop ______
Pee, Potter’s
What are the causes of Potter’s syndrome?
ARPKD
Posterior urethral valves
Bilateral renal agenesis
What happens in Horseshoe kidney?
Inferior poles of both kidneys fuse
As the kidneys _____ from the pelvis during fetal development, the horseshoe kidneys get trapped under _________ and remain ________ in the abdomen
ascend, inferior mesenteric artery, low
The kidneys function ______ in horseshoe kidney
normally
Horseshoe kidney is associated with _______
Turner syndrome
Multicystic dysplastic kidney is due to the interaction between _________
ureteric bud and metanephric mesencyme
MDK leads to a _________ kidney consisting of _______ and __________
nonfunctional kidney, cysts, connective tissue
If MDK is unilateral it is generally ________ with compensatory ________ of contralateral kidney
asymptomatic, hypertrophy
MDK is often diagnosed _______ via ________
prenatally, ultrasound
