Embryology Flashcards
What is the embrological orgins of the following
retina - neurosensory and RPE
epithelial lining of iris and ciliary body
optic nerves
Neuroectoderm
The optic nerve, iris, and choroid are made of neuroectoderm and are completed when the optic (choroidal) fissure of the optic vesicle closes completely around the mesoderm that becomes the hyaloid artery at 6 weeks.
What is the embrological orgins of the following lens corneal epithelium conjunctival epithelium lacrimal gland nasolacrimal system Meibomian glands
surface ectoderm
The eye lid is formed by surface ectoderm, later in ocular development.
What is the embryological origin of the following
sclera iris stroma cornea: stroma and endothelium TM and Schlemm's canal extraocular muscle ciliary muscle connective tissue and bony structure of the orbit
Neural crest
What is the embrological orgins of the following extraocular muscles endothelial lining of blood vessels of the eye blood vessels in sclera and choroid sclera vitreous suspensory fibres angle outflow apparatus
Mesoderm
what defects may arise from incomplete closing of optic fissure
coloboma of iris ciliary body retina/RPE Optic disc Optic nerve
what mutation can cause renal-coloboma syndrome (papillorenal syndrome)
PAX2 mutations
Autosomal dominant inheritance
what is more common in optic cup and optic stalk
Optic cup –> PAX6
OPTIC STALK –> PAX2
what is the cornea made of
a composite of neural crest (stroma and endothelium) and ectoderm (epithelium)
What infections can lead to congenital cataracts?
Rubella/toxoplasmosis/CMV/herpes simplex
Temporal sclera arises from whic layer
mesoderm
what is the lens derived from
surface ectoderm
what is the first cell in th e eye to produce melanin?
RPE
what are the two vascular networks in eye?
retinal vasculature, glia associated - inner
vessels of uveal tract - outer
what established the blood retina barrier
tight junctions in retinal vessels b/w endothelial and epithelial cells
what forms the outer blood retinal barrier
the RPE
